Afatinib dichloro impurity CAS 2223677-63-0
| CAS No. | 2223677-63-0 |
| Molecular Formula | C24H25Cl2N5O3 |
| Molecular Weight | 502.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Afatinib dichloro impurity (CAS 2223677-63-0), molecular formula C24H25Cl2N5O3 and molecular weight 502.39 g/mol, is a CATO reference standard with documented purity and traceability.
Afatinib dichloro impurity (C24H25Cl2N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25Cl2N5O3 |
| Molecular Weight | 502.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib Impurity 4 (CAS CATO-C4X-10064)
- Afatinib Impurity 11 (CAS CATO-C4X-100611)
- Afatinib Impurity 57 (CAS CATO-C4X-100657)
- Afatinib Impurity 87 (CAS CATO-C4X-100687)
- Afatinib-d6 (CAS 1313874-96-2)
- Afatinib Impurity 47 (CAS CATO-C4X-100647)
- Afatinib Impurity 36 (CAS CATO-C4X-100636)
- Afatinib Impurity 63 (CAS CATO-C4X-100663)
Recommended Standards
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