Afatinib Impurity 87 CAS CATO-C4X-100687
| CAS No. | CATO-C4X-100687 |
| Molecular Formula | C23H22ClFN6O4 |
| Molecular Weight | 500.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 500.91 g/mol gives Afatinib Impurity 87 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Afatinib Impurity 87 (CAS CATO-C4X-100687) is a certified pharmaceutical impurity reference standard with the molecular formula C23H22ClFN6O4 and a molecular weight of 500.91 g/mol.
Afatinib Impurity 87 (C23H22ClFN6O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afatinib Impurity 87 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H22ClFN6O4 |
| Molecular Weight | 500.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Afatinib Standards
- Afatinib Impurity 57 (CAS CATO-C4X-100657)
- Afatinib Impurity 11 (CAS CATO-C4X-100611)
- Afatinib dichloro impurity (CAS 2223677-63-0)
- Afatinib Impurity 4 (CAS CATO-C4X-10064)
- Afatinib-d6 (CAS 1313874-96-2)
- Afatinib Impurity 36 (CAS CATO-C4X-100636)
- Afatinib Impurity 63 (CAS CATO-C4X-100663)
- Afatinib Impurity 94 (CAS CATO-C4X-100694)
Recommended Standards
- Rilematovir, >98% (HPLC) (CAS 1383450-81-4)
- 3-O-tert-Butyldimethylsilyl Cholesterol (CAS 57711-50-9)
- (E)-2-((4-chlorobenzyl)thio)quinoline-3-carbaldehyde O-(3-(trifluoromethyl)benzoyl) oxime (CAS 866049-68-5)
- N-Nitroso Flucloxacillin Impurity 22 (CAS CATO-C4X-164722)
- Riociguat EP Impurity A (CAS 625115-52-8)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
- Ubidecarenone Impurity 16 (CAS 2538537-69-6)
- Ormeloxifene (CAS 78994-24-8)
- Ethyl 2,5-difluorobenzoylformate (CAS 1049131-01-2)
- 2-((2-Isopropyl-5-methylcyclohexyl)amino)propan-1-ol (CAS 1218194-46-7)
- 1-(Methylamino)cyclohexane-1-carboxylic acid (CAS 98552-54-6)
- 3-Chloro-2-(3-ethoxyphenoxy)aniline (CAS 946772-80-1)
- Carbomycin (CAS 4564-87-8)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com