Afatinib Impurity 68 CAS CATO-C4X-100668
| CAS No. | CATO-C4X-100668 |
| Molecular Formula | C23H22ClFN4O3 |
| Molecular Weight | 456.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Afatinib Impurity 68 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Afatinib Impurity 68 (CAS CATO-C4X-100668), a pharmacopoeial impurity reference standard (molecular formula C23H22ClFN4O3, MW 456.90 g/mol) used for the identification and quantification of trace impurities in APIs.
Afatinib Impurity 68 (C23H22ClFN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afatinib Impurity 68 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H22ClFN4O3 |
| Molecular Weight | 456.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 14 (CAS 2121530-37-6)
- Afatinib Impurity 19 (CAS 2223677-58-3)
- Afatinib Impurity 18 (CAS CATO-C4X-100618)
- Afatinib Impurity 50 (CAS 2413212-25-4)
- Afatinib Impurity 79 (CAS CATO-C4X-100679)
- Afatinib Impurity 5 (CAS 2223677-62-9)
- Afatinib Impurity 34 (CAS CATO-C4X-100634)
- Afatinib Impurity 7 (CAS 2223677-64-1)
Recommended Standards
- 2-Chloro-N'-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridine-6-carbonyl)benzenesulfonohydrazide (CAS 866137-85-1)
- Dapagliflozin Impurity 201 (CAS CATO-C4X-1138201)
- 2-(4-Ethoxyphenyl)-4-oxo-4H-chromen-3-yl 4-chlorobenzenesulfonate (CAS 298215-03-9)
- (2E)-2-(Benzenesulfonyl)-3-{2-[(4-chlorophenyl)sulfanyl]-5-nitrophenyl}prop-2-enenitrile (CAS 1025642-11-8)
- Sildenafil Impurity 291 (CAS CATO-C4X-1128291)
- Tamsulosin EP Impurity F HCl (CAS 1051368-80-9)
- Phenylephrine Impurity 37 (CAS 70935-14-7)
- 3,6-Dichloro-2-fluoromandelic acid (CAS 1803727-95-8)
- (2R,3R,5R)-5-(2,6-Diamino-9H-purin-9-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 156130-57-3)
- imidazo[1,2-a]pyridine-5-carbaldehyde (CAS 372147-50-7)
- 5,6-Difluoro-1,4-dihydro-1,4-epoxynaphthalene (CAS 173276-84-1)
- 6-chloro-3-iodo-2-(trifluoromethyl)pyridine (CAS 945717-57-7)
- 3-Methyl-4-piperidinomethyl benzophenone (CAS 898770-95-1)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com