Afatinib Impurity 81 CAS CATO-C4X-100681
| CAS No. | CATO-C4X-100681 |
| Molecular Formula | C16H15ClFN5 |
| Molecular Weight | 331.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 331.78 g/mol gives Afatinib Impurity 81 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Afatinib Impurity 81 (CAS CATO-C4X-100681, C16H15ClFN5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, Afatinib Impurity 81 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 331.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afatinib Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15ClFN5 |
| Molecular Weight | 331.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib Impurity 83 (CAS CATO-C4X-100683)
- Afatinib Impurity 53 (CAS 1449430-45-8)
- Afatinib Impurity 22 (CAS 162012-67-1)
- Afatinib Impurity 51 (CAS CATO-C4X-100651)
- Afatinib Impurity 54 (CAS 2831861-00-6)
- Afatinib Impurity 80 (CAS CATO-C4X-100680)
- Afatinib Impurity 76 (CAS CATO-C4X-100676)
- Afatinib Impurity 65 (CAS CATO-C4X-100665)
Recommended Standards
- N-(5-chloro-2-hydroxyphenyl)-4-phenyl-1,2,3-thiadiazole-5-carboxamide (CAS 860649-81-6)
- 3-[(3-Chlorophenyl)amino]-2-phenyl-1H-inden-1-one (CAS 1020252-39-4)
- N-(2-Chlorophenyl)-4-(3-nitrophenyl)-1,3-thiazol-2-amine (CAS 477838-02-1)
- 4-(4-Chlorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylic acid (CAS 1233334-75-2)
- Cefminox Impurity 8 (CAS CATO-C4X-19268)
- Olmesartan Impurity 59 (CAS 971-85-7)
- Valsartan Impurity 32 (CAS CATO-C4X-105732)
- 4-Amino-6-(difluoromethyl)-3-methoxypyridin-2-ol (CAS 1805211-38-4)
- 4-Pentenoyl chloride (CAS 39716-58-0)
- Acid-PEG3-C2-Boc (CAS 1807539-06-5)
- 2-[(1Z)-1-Cyano-2-(dimethylamino)eth-1-en-1-yl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (CAS 338786-57-5)
- (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-(2-(trifluoromethyl)benzyl)propanoic acid (CAS 1260616-24-7)
- 3-(3-Hydroxypiperidin-1-yl)tetrahydrothiophene 1,1-dioxide (CAS 1247071-46-0)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com