Aripiprazole Impurity 45 CAS CATO-C4X-100845
| CAS No. | CATO-C4X-100845 |
| Molecular Formula | C22H26Cl4N4 |
| Molecular Weight | 488.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Aripiprazole Impurity 45 (CAS CATO-C4X-100845, C22H26Cl4N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aripiprazole Impurity 45 (C22H26Cl4N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H26Cl4N4 |
| Molecular Weight | 488.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Aripiprazole Standards
- Aripiprazole-d8 N,N-Dioxide (CAS 1346603-98-2)
- Aripiprazole N,N-Dioxide (CAS 573691-13-1)
- Aripiprazole-d8 N1-Oxide (CAS 1346600-34-7)
- Aripiprazole-d8 N4-Oxide (CAS 1346600-39-2)
- Aripiprazole Impurity 70 (CAS CATO-C4X-100870)
- Aripiprazole, thio- (CAS 573691-04-0)
- Aripiprazole Impurity 13 (CAS 573691-11-9)
- Aripiprazole EP Impurity F (CAS 573691-09-5)
Recommended Standards
- 3,5-Bis((4-bromobenzyl)thio)-1,2,4-thiadiazole (CAS 332110-09-5)
- 2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-ylidene}-N-{[(4-chlorophenyl)carbamoyl]amino}acetamide (CAS 321430-53-9)
- 3-(6-Fluoro-1H-indol-3-yl)-2-(4-iodobenzenesulfonamido)propanoic acid (CAS 1796902-05-0)
- 6-Chloro-1-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-3-morpholinoquinoxalin-2(1H)-one (CAS 303986-20-1)
- Finasteride Impurity 15 (CAS 140375-21-9)
- Bumetanide Impurity 113 (CAS CATO-C4X-1986113)
- Atogepant Impurity 7 (CAS 1375541-78-8)
- N'-[2,5-Bis(2,2,2-trifluoroethoxy)benzoyl]-4-chlorobenzohydrazide (CAS 860788-22-3)
- Methyl 5-oxocyclohex-3-ene-1-carboxylate (CAS 37051-55-1)
- 3-(5-Fluoropyridin-2-yl)thiazolidine (CAS 1707358-04-0)
- 2-(Cyclohexylthio)benzenamine (CAS 37535-87-8)
- 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzonitrile (CAS 128886-91-9)
- 2-((3-Bromophenyl)thio)pentan-3-one (CAS 1339643-98-9)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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