Baclofen Impurity 68 CAS CATO-C4X-101268
| CAS No. | CATO-C4X-101268 |
| Molecular Formula | C14H20ClNO2 |
| Molecular Weight | 269.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Baclofen Impurity 68.
As a process- or degradation-related impurity, Baclofen Impurity 68 (CAS CATO-C4X-101268, C14H20ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Baclofen Impurity 68 (C14H20ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 269.77 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H20ClNO2 |
| Molecular Weight | 269.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Baclofen Standards
- Baclofen Impurity 47 (CAS CATO-C4X-101247)
- Baclofen Impurity 79 (CAS 947583-11-1)
- Baclofen impurity 20 (CAS 137310-15-7)
- Baclofen impurity 45 (CAS CATO-C4X-101245)
- Baclofen Impurity 63 (CAS CATO-C4X-101263)
- Baclofen Impurity 64 (CAS CATO-C4X-101264)
- Baclofen Impurity 35 (CAS CATO-C4X-101235)
- Baclofen Impurity 39 (CAS CATO-C4X-101239)
Recommended Standards
- S-Metolachlor metabolite CGA 41638 (CAS 65513-61-3)
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- Sertraline Impurity 46 (CAS CATO-C4X-134446)
- Elagolix Impurity 113 (CAS CATO-C4X-2068113)
- WX390 Impurity 2 (CAS 212517-19-6)
- Linagliptin Impurity 3 (CAS CATO-C4X-11013)
- 2-Cyclopropoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1418132-45-2)
- N-(1-(1-benzylpyrrolidin-3-yl)ethyl)thietan-3-amine (CAS 2008708-58-3)
- Clindamycin Impurity 152 (CAS CATO-C4X-1341152)
- 4-Butyl-5-methoxy-1,2-diphenyl-1H-pyrazol-3(2H)-one (CAS 27258-01-1)
- (4-Ethoxyphenyl)(piperidin-4-yl)methanone (CAS 933216-88-7)
- Lithium 2-(1-cyanocyclopropyl)nicotinate (CAS 1956332-12-9)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
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