Lorazepam Impurity 18 CAS CATO-C4X-104118
| CAS No. | CATO-C4X-104118 |
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lorazepam Impurity 18 (CAS CATO-C4X-104118, C16H12Cl2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H12Cl2N2O2, Lorazepam Impurity 18 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 335.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lorazepam Standards
Recommended Standards
- Clopidogrel Impurity 58 (CAS CATO-C4X-102958)
- Methyl 2-(4-(benzyloxy)-3-bromophenyl)acetate (CAS 101111-25-5)
- N-(1,1-Dioxidotetrahydrothiophen-3-yl)dodecanamide (CAS 24373-83-9)
- 2-[2-(4-Bromo-phenyl)-ethyl]-6-hydroxy-benzoic acid methyl ester (CAS 1171923-98-0)
- Roxadustat Impurity 128 (CAS CATO-C4X-2213128)
- Telmisartan Impurity 29 (CAS 1132638-92-6)
- Salbutamol Impurity 83 (CAS CATO-C4X-117683)
- (Trp3,Arg5)-Ghrelin (H-6456.0001) (CAS 848442-59-1)
- DPTQO8-2Br (CAS 1233872-22-4)
- 5-Bromo-3,4-difluoro-2-methoxyphenylboronic acid (CAS 1256346-43-6)
- Methyl 4-bromo-3-(5-bromothiophen-2-yl)-1h-pyrazole-5-carboxylate (CAS 1312683-39-8)
- 2-(2-Aminopropan-2-yl)-1H-imidazole-4-carboxylic acid (CAS 1344692-67-6)
- 1-{[3-(chloromethyl)phenyl]methyl}piperidine hydrochloride (CAS 104126-78-5)
- Semaglutide impurity 77 (CAS CATO-C4X-222677)
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