Regorafenib Impurity 42 CAS CATO-C4X-104742
| CAS No. | CATO-C4X-104742 |
| Molecular Formula | C12H9FN2O3 |
| Molecular Weight | 248.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Regorafenib Impurity 42 (CAS CATO-C4X-104742) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9FN2O3 and a molecular weight of 248.21 g/mol.
Based on its molecular formula C12H9FN2O3, Regorafenib Impurity 42 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 248.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9FN2O3 |
| Molecular Weight | 248.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 39 (CAS CATO-C4X-104739)
- Regorafenib Impurity 44 (CAS CATO-C4X-104744)
- Regorafenib Impurity 47 (CAS CATO-C4X-104747)
- Regorafenib Impurity 35 (CAS CATO-C4X-104735)
- Regorafenib Impurity 5 (CAS 19448-54-5)
- Regorafenib Impurity 79 (CAS CATO-C4X-104779)
- Regorafenib Impurity 19 (CAS 350602-02-7)
- Regorafenib Impurity 64 (CAS CATO-C4X-104764)
Recommended Standards
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- Spiramycin EP impurity F (CAS CATO-C4X-232510)
- Perampanel Impurity 22 (CAS CATO-C4X-243022)
- Rivaroxaban Impurity 136 (CAS 36157-42-3)
- 5-Chloro-8-iodoquinolin-2(1H)-one (CAS 2005932-77-2)
- Osmium(III) chloride hydrate (CAS 14996-60-2)
- 2-Bromo-5-(chloromethyl)-1,3,4-thiadiazole (CAS 2091638-73-0)
- ((1S,2R,3R)-3-(6-Amino-9H-purin-9-yl)cyclobutane-1,2-diyl)dimethanol (CAS 126187-01-7)
- (2-Cyano-4-(piperazin-1-yl)phenyl)boronic acid (CAS 2225155-93-9)
- (3Z)-3-{[4-(2-chloroacetyl)-1H-pyrrol-2-yl]methylidene}-2,3-dihydro-1H-indol-2-one (CAS 866038-33-7)
- Cyclolinopeptide B (CAS 193139-41-2)
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