Regorafenib Impurity 35 CAS CATO-C4X-104735
| CAS No. | CATO-C4X-104735 |
| Molecular Formula | C13H11FN2O2 |
| Molecular Weight | 246.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Regorafenib Impurity 35 (CAS CATO-C4X-104735) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11FN2O2 and a molecular weight of 246.24 g/mol.
Structurally, Regorafenib Impurity 35 (C13H11FN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 246.24 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H11FN2O2 |
| Molecular Weight | 246.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 39 (CAS CATO-C4X-104739)
- Regorafenib Impurity 42 (CAS CATO-C4X-104742)
- Regorafenib Impurity 44 (CAS CATO-C4X-104744)
- Regorafenib Impurity 47 (CAS CATO-C4X-104747)
- Regorafenib Impurity 19 (CAS 350602-02-7)
- Regorafenib Impurity 64 (CAS CATO-C4X-104764)
- Regorafenib Impurity 5 (CAS 19448-54-5)
- Regorafenib Impurity 79 (CAS CATO-C4X-104779)
Recommended Standards
- Diphenylphosphinic acid ethyl ester (CAS 1733-55-7)
- Sildenafil Impurity 53 (CAS 2021224-02-0)
- Salicylic Acid Impurity 26 (CAS 83957-15-7)
- Cefdinir Impurity 53 (CAS 178422-40-7)
- Omeprazole Impurity 44 (CAS 69818-23-1)
- Vortioxetine Impurity 104 (CAS CATO-C4X-1056104)
- Epinastine Impurity 58 (CAS CATO-C4X-184058)
- 2,6-Bis(trimethylsilyl)-4h-cyclopenta[1,2-b:5,4-b']dithiophen-4-one (CAS 1187970-48-4)
- N-(2-methoxy-5-methylphenethyl)propan-2-amine (CAS 802317-24-4)
- Depropylamino Chloro Propafenone-d5 (CAS 1346598-65-9)
- 3-(1-Methyl-1h-indol-3-yl)propan-1-ol (CAS 29957-90-2)
- Ethyl 5-(6-methylpyridin-3-yl)thiophene-2-carboxylate (CAS 1187170-31-5)
- 7-Benzyl-3-ethoxy-6-ethyl-2H-thiazolo[3,2-a]pyrimidin-5(3H)-one (CAS 199852-32-9)
- Cyclolinopeptide B (CAS 193139-41-2)
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