Regorafenib Impurity 59 CAS CATO-C4X-104759
| CAS No. | CATO-C4X-104759 |
| Molecular Formula | C28H19ClF7N5O3 |
| Molecular Weight | 641.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 641.92 g/mol gives Regorafenib Impurity 59 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Regorafenib Impurity 59 (CAS CATO-C4X-104759) is a certified pharmaceutical impurity reference standard with the molecular formula C28H19ClF7N5O3 and a molecular weight of 641.92 g/mol.
The molecular framework of Regorafenib Impurity 59 (C28H19ClF7N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 59 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H19ClF7N5O3 |
| Molecular Weight | 641.92 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Regorafenib Standards
- Regorafenib Impurity 57 (CAS CATO-C4X-104757)
- Regorafenib Impurity 11 (CAS CATO-C4X-104711)
- Regorafenib Impurity 12 (CAS CATO-C4X-104712)
- Regorafenib EP Impurity D (CAS 2438857-80-6)
- Regorafenib Impurity 84 (CAS CATO-C4X-104784)
- Regorafenib Impurity 9 (CAS CATO-C4X-10479)
- Regorafenib-13C-d3 N-Oxide (CAS 835621-11-9 (Unlabeled))
- Regorafenib Impurity 13 (CAS 835621-11-9)
Recommended Standards
- (2S,3R,4E)-2-tert-Butyloxycarbonylamino-1-triphenylmethyloxy-4-octadecen-2-ol (CAS 299172-62-6)
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- Bis(3,5-dibromosalicyl) Fumarate (CAS 71337-53-6)
- Dichloro[1-[[4-(1,1-dimethylethyl)phenyl]methyl]-1,3-dihydro-3-[(3-methoxyphenyl)methyl]-2H-benzimidazol-2-ylidene](pyridine)palladium (CAS 2304464-58-0)
- Landiolol Impurity 10 (CAS CATO-C4X-262110)
- Fudosteine Impurity 16 HCl (CAS CATO-C4X-144716)
- Ritonavir EP Impurity J (CAS 162849-95-8)
- (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride (CAS 1353980-53-6)
- 6-chloro-1-hexyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 2711002-60-5)
- 3-Octen-2-ol (CAS 76649-14-4)
- 2-(But-3-en-1-yl)-2-formylcyclohexyl acetate (CAS 143288-06-6)
- 4-(Chloromethyl)-1-iodo-2-methylbenzene (CAS 183000-57-9)
- 2-(Dimethylamino)-5-ethylphenol (CAS 1243453-70-4)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com