Regorafenib Impurity 57 CAS CATO-C4X-104757
| CAS No. | CATO-C4X-104757 |
| Molecular Formula | C27H20ClF4N5O4 |
| Molecular Weight | 589.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Regorafenib Impurity 57 (CAS CATO-C4X-104757) is a certified pharmaceutical impurity reference standard with the molecular formula C27H20ClF4N5O4 and a molecular weight of 589.93 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Regorafenib Impurity 57 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 589.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Regorafenib Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H20ClF4N5O4 |
| Molecular Weight | 589.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Regorafenib Standards
- Regorafenib Impurity 12 (CAS CATO-C4X-104712)
- Regorafenib EP Impurity D (CAS 2438857-80-6)
- Regorafenib Impurity 84 (CAS CATO-C4X-104784)
- Regorafenib Impurity 59 (CAS CATO-C4X-104759)
- Regorafenib Impurity 9 (CAS CATO-C4X-10479)
- Regorafenib-13C-d3 N-Oxide (CAS 835621-11-9 (Unlabeled))
- Regorafenib Impurity 13 (CAS 835621-11-9)
- Regorafenib Impurity 16 (CAS 1343498-71-4)
Recommended Standards
- 2-{N-[5-(benzyloxy)-2,4-dichlorophenyl]4-methylbenzenesulfonamido}-N-(4-chlorophenyl)acetamide (CAS 338961-82-3)
- (10R,12R,13S)-rel-(+)-4-chloro-6,7,10,11,12,13-hexahydro-10,12,13,15-tetrahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,5,14,16-tetrone 934464-78-5 (CAS 934464-78-5)
- Fluralaner Impurity 51 (CAS 1215216-63-9)
- Rodatristat-Ethyl (CAS 1673571-51-1)
- Dapagliflozin impurity 214 (CAS CATO-C4X-1138214)
- Captopril Impurity 8 (CAS 74345-73-6)
- Sodium Valproate EP Impurity C (CAS 62391-99-5)
- 1-(3-(Methylsulfonyl)-5-(trifluoromethyl)pyridin-2-yl)ethan-1-one (CAS 1400872-34-5)
- 4-((Methylsulfonyl)methyl)-1H-imidazole (CAS 24100-20-7)
- 3,4-Dihydro-1H-benzo[d][1,2]oxazine (CAS 14859-23-5)
- 2,4,6-Trifluoro-3,5-dimethylbenzaldehyde (CAS 1951441-62-5)
- CAL 130 hydrochloride (CAS 1431697-78-7)
- 1-(5-Chloropyrimidin-2-yl)ethan-1-one (CAS 1822666-76-1)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
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