Hydroxychloroquine impurity 86 CAS CATO-C4X-183586
| CAS No. | CATO-C4X-183586 |
| Molecular Formula | C20H28ClN3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydroxychloroquine impurity 86.
As a process- or degradation-related impurity, Hydroxychloroquine impurity 86 (CAS CATO-C4X-183586, C20H28ClN3O2H2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Hydroxychloroquine impurity 86 (C20H28ClN3O2H2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 475.98 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H28ClN3O2 H2O4S |
| Molecular Weight | 475.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
Recommended Standards
- Finasteride EP Impurity A (CAS 98319-24-5)
- Oxacillin Impurity 31 (CAS CATO-C4X-232131)
- Revefenacin Impurity 63 (CAS CATO-C4X-203163)
- 2-Mercapto-N'-(2-mercaptobenzoyl)benzohydrazide (CAS 292615-41-9)
- 1-(tert-Butyl)-1H-pyrazole-4-carbaldehyde (CAS 127949-06-8)
- 2-(6-Bromo-5-(difluoromethyl)-2-hydroxypyridin-3-yl)acetic acid (CAS 1805349-02-3)
- Apixaban Impurity 61 (CAS 62522-25-2)
- (4-Ethoxy-3-(trifluoromethyl)phenyl)methanamine (CAS 1206593-27-2)
- N,N-Dimethyl-4-propanoyl-1H-pyrrole-2-carboxamide (CAS 338404-12-9)
- (Tyr9)-Cholecystokinin Octapeptide (sulfated) (H-9770.0005) (CAS 96607-61-3)
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