Ceritinib Impurity 76 CAS CATO-C4X-104876
| CAS No. | CATO-C4X-104876 |
| Molecular Formula | C28H36ClN5O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 672.16 g/mol gives Ceritinib Impurity 76 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ceritinib Impurity 76 (CAS CATO-C4X-104876), a pharmacopoeial impurity reference standard (molecular formula C28H36ClN5O3SC2HF3O2, MW 672.16 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Ceritinib Impurity 76 (C28H36ClN5O3SC2HF3O2) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 672.16 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H36ClN5O3S 2*C2HF3O2 |
| Molecular Weight | 672.16 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 86 (CAS /)
- Ceritinib (CAS 1032900-25-6)
- Ceritinib dihydrochloride (CAS 1380575-43-8)
- Ceritinib Impurity 88 (CAS 1823331-67-4)
- Ceritinib Impurity 87 (CAS 2976-70-7（free base))
- Ceritinib Impurity 85 (CAS 761440-17-9)
- Ceritinib Impurity 19 (CAS 771555-72-7)
- Ceritinib Impurity 2 (CAS 861343-73-9)
Recommended Standards
- Cefalotin EP Impurity C/Cefoperazone EP Impurity E/Cefazolin EP Impurity H (CAS 957-68-6)
- Tafluprost Impurity 9 (CAS 1563176-58-8)
- Tirofiban Impurity 43 (CAS CATO-C4X-125443)
- Ethyl 2-((5-fluoro-2-methoxyphenyl)thio)-2-oxoacetate (CAS 1443342-22-0)
- 4-(3-Methoxybenzoyl)tetrahydro-2H-pyran-4-carbonitrile (CAS 1403565-01-4)
- 2-{4-Aminobicyclo[2.2.2]octan-1-yl}acetic acid hydrochloride (CAS 28345-44-0)
- N-(3-fluoro-2-methyl-6-nitrophenyl)acetamide (CAS 156243-41-3)
- 2-(Tetrahydro-2H-thiopyran-4-yl)ethan-1-ol (CAS 123095-08-9)
- 5-Bromo-1-(cyclopropylmethyl)indoline (CAS 1784059-18-2)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com