Ceritinib Impurity 75 CAS CATO-C4X-104875
| CAS No. | CATO-C4X-104875 |
| Molecular Formula | C28H36BrN5O3S |
| Molecular Weight | 602.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ceritinib Impurity 75.
Ceritinib Impurity 75 (CAS CATO-C4X-104875) is a certified pharmaceutical impurity reference standard with the molecular formula C28H36BrN5O3S and a molecular weight of 602.59 g/mol.
Ceritinib Impurity 75 (C28H36BrN5O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ceritinib Impurity 75 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H36BrN5O3S |
| Molecular Weight | 602.59 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 11 (CAS CATO-C4X-1048911)
- Ceritinib Impurity 13 (CAS CATO-C4X-1048913)
- Ceritinib Impurity 9 (CAS CATO-C4X-104889)
- Ceritinib Impurity 66 (CAS CATO-C4X-104866)
- Ceritinib Impurity 14 (CAS CATO-C4X-1048914)
- Ceritinib Impurity 18 (CAS CATO-C4X-104818)
- Ceritinib Impurity 67 (CAS CATO-C4X-104867)
- Ceritinib Impurity 61 (CAS CATO-C4X-104861)
Recommended Standards
- 2,9-Bis(4-methoxyphenyl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone (CAS 6424-77-7)
- N1-(4-((2-Carbamoylpyridin-4-yl)oxy)phenyl)-N3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)isophthalamide (CAS 1334499-71-6)
- Remdesivir Impurity 31 (CAS CATO-C4X-210031)
- Linezolid Impurity 43 (CAS 1798014-14-8)
- Indacaterol Impurity 93 (CAS 1640894-03-6)
- Niraparib Impurity 21 (CAS 1263284-59-8)
- Methotrexate EP Impurity E (CAS 19741-14-1)
- (11aS)-10,11,12,13-Tetrahydro-N,N-bis(1-methylethyl)diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine (CAS 477559-83-4)
- 2-Methyl-2'-(pyrrolidine-3-carbonyl)-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261979-53-6)
- (1,1,1-Trifluoropropan-2-yl)benzene (CAS 161361-16-6)
- (4,5-Dimethyl-3-thienyl)methanol (CAS 119072-18-3)
- 4-(4-Nitrophenyl)-2-pyrimidinamine (CAS 99361-84-9)
- N-Benzyl-2-chloro-N-phenylacetamide (CAS 2653-14-7)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
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