Ceritinib Impurity 78 CAS CATO-C4X-104878
| CAS No. | CATO-C4X-104878 |
| Molecular Formula | C4H4N2O3 |
| Molecular Weight | 128.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ceritinib Impurity 78.
As a process- or degradation-related impurity, Ceritinib Impurity 78 (CAS CATO-C4X-104878, C4H4N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ceritinib Impurity 78 (C4H4N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H4N2O3 |
| Molecular Weight | 128.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Nitrogen Atoms | 2 |
Related Ceritinib Standards
- Ceritinib Impurity 77 (CAS CATO-C4X-104877)
- Ceritinib Impurity 19 (CAS 771555-72-7)
- Ceritinib Impurity 30 (CAS CATO-C4X-104830)
- Ceritinib Impurity 88 (CAS 1823331-67-4)
- Ceritinib Impurity 15 (CAS CATO-C4X-104815)
- Ceritinib Impurity 36 (CAS CATO-C4X-104836)
- Ceritinib Impurity 40 (CAS CATO-C4X-104840)
- Ceritinib Impurity 50 (CAS CATO-C4X-104850)
Recommended Standards
- C592309ECU 670-54-2 Tetracyanoethylene Ethenetetracarbonitrile Ethylenetetracarbonitrile 1,1,2,2-Ethenetetracarbonitrile AI3-28756 delta2,2'-Bimalononitrile CCRIS 2643 EINECS 211-578-0 Ethene, tetracyano- NSC 24833 delta(sup 2,2')-Bimalononitrile TCNE Tetracyanoethene 1,1,2,2-Tetracyanoethene 1,1,2,2-Tetracyanoethylene Tetrakyanethylen [Czech] Tetrakyanethylen UNII-C592309ECU (CAS 670-54-2)
- N-Nitroso Bromhexine impurity 58 (CAS CATO-C4X-106058)
- 2-Trifluoromethyl-2-propanol (CAS 507-52-8)
- Ribavirin Impurity 52 (CAS 3641-13-2)
- Furosemide Impurity 26 (CAS CATO-C4X-140226)
- Lenvatinib Impurity 1 (CAS 417714-14-8)
- Methotrexate Impurity 31 (CAS CATO-C4X-115431)
- 2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)thiophen-2-yl]-5-[(piperidin-1-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-ol (CAS 439111-89-4)
- 4-(2-(Bromomethyl)butyl)thiazole (CAS 1465067-90-6)
- Homatropine Methyl Bromide (CAS 80-49-9)
- 5-(Methylsulfonyl)-4-(4-nitrophenyl)thiazol-2-amine (CAS 1707668-45-8)
- N-(2-(1H-Indol-3-yl)ethyl)butyramide (CAS 76049-36-0)
- 2-Iodo-6-methylpyridine (CAS 62674-71-9)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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