N-Nitroso Bromhexine impurity 58 CAS CATO-C4X-106058
| CAS No. | CATO-C4X-106058 |
| Molecular Formula | C4H4N2O3 |
| Molecular Weight | 128.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-Nitroso Bromhexine impurity 58.
As a process- or degradation-related impurity, N-Nitroso Bromhexine impurity 58 (CAS CATO-C4X-106058, C4H4N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of N-Nitroso Bromhexine impurity 58 (C4H4N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-Nitroso Bromhexine impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4N2O3 |
| Molecular Weight | 128.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Nitroso-4-piperidone (CAS 55556-91-7)
- N-Nitroso-2-methylpiperidin (CAS 14026-03-0)
- N-Nitroso Chlorcyclizine EP Impurity A (CAS 16339-07-4)
- N-nitroso Diallyl Amine (CAS 16338-97-9)
- N-Nitroso Metronidazole Impurity 33 (CAS CATO-C4X-140533)
- N-Nitroso-L-azetidine-2-Carboxylic Acid (CAS 30248-47-6)
- N-Nitroso-3-Hydroxy Pyrrolidone (CAS 2826147-23-1)
- 1-Nitroso-3-Piperidinol (CAS 55556-85-9)
Recommended Standards
- Ceritinib Impurity 78 (CAS CATO-C4X-104878)
- Ribavirin Impurity 52 (CAS 3641-13-2)
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- Cefazolin USP RC A (CAS 21732-17-2)
- Pazopanib Impurity 1 HCl (CAS 2518115-74-5)
- Empagliflozin impurity 254 (CAS CATO-C4X-1065254)
- Cetilistat Impurity 3 (CAS 282526-78-7)
- 1,3-dimethylguanidine hydroiodide (CAS 57069-85-9)
- N-(1-(furan-2-yl)ethyl)-1-phenylbut-3-en-1-amine (CAS 436088-63-0)
- 2-fluoro-4-[4-(propan-2-yloxy)phenyl]aniline (CAS 1183422-13-0)
- N-Hydroxy-2-methyl-5-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1,3-dioxane-2-carboxamide (CAS 1297530-08-5)
- 4-((5-Aminopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate (CAS 2093386-40-2)
- Arotinolol Impurity 72 (CAS CATO-C4X-185472)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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