Ibrutinib Impurity 135 CAS CATO-C4X-1064135
| CAS No. | CATO-C4X-1064135 |
| Molecular Formula | C27H27N5O2 |
| Molecular Weight | 453.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ibrutinib Impurity 135 (C27H27N5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Ibrutinib Impurity 135 (CAS CATO-C4X-1064135) is a certified pharmaceutical impurity reference standard with the molecular formula C27H27N5O2 and a molecular weight of 453.54 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ibrutinib Impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H27N5O2 |
| Molecular Weight | 453.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Ibrutinib Standards
- Ibrutinib Impurity 113 (CAS CATO-C4X-1064113)
- Ibrutinib Impurity 105 (CAS 2988167-31-1)
- Ibrutinib Impurity 12 (CAS 2417548-74-2)
- Ibrutinib Impurity 42 (CAS 2052279-49-7)
- Ibrutinib Impurity 72 (CAS CATO-C4X-106472)
- Ibrutinib Impurity 75 (CAS 2437254-47-0)
- Ibrutinib Impurity 150 (CAS 1839099-23-8)
- Ibrutinib Impurity N1 (CAS 1838132-94-7)
Recommended Standards
- UM171 (CAS 1448724-09-1)
- Tofacitinib Impurity 103 (CAS CATO-C4X-1079103)
- SB-590885 (CAS 405554-55-4)
- Tofacitinib Impurity 240 (CAS CATO-C4X-1079240)
- Melitracen Impurity 12 (CAS CATO-C4X-120212)
- Salbutamol Impurity 125 (CAS CATO-C4X-1176125)
- Vildagliptin Impurity 112 (CAS CATO-C4X-1100112)
- 4-(butylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione (CAS 1809556-60-2)
- 4-(1-ethyl-1H-imidazol-4-yl)phenol (CAS 74730-85-1)
- 4-(1,1-Difluoroethyl)pyridin-2-amine (CAS 1522240-28-3)
- 9-Bromo-2,6-dichloroanthracene (CAS 88847-74-9)
- Linagliptin Impurity 90 (CAS 915226-43-6)
- Methyldopa EP Impurity D HBr (CAS 2799-15-7 (free base))
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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