Ibrutinib Impurity 75 CAS 2437254-47-0
| CAS No. | 2437254-47-0 |
| Molecular Formula | C25H24N6O3 |
| Molecular Weight | 456.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ibrutinib Impurity 75 (C25H24N6O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ibrutinib Impurity 75 (CAS 2437254-47-0, C25H24N6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H24N6O3 |
| Molecular Weight | 456.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 105 (CAS 2988167-31-1)
- Ibrutinib Impurity 12 (CAS 2417548-74-2)
- Ibrutinib Impurity 42 (CAS 2052279-49-7)
- Ibrutinib Impurity 72 (CAS CATO-C4X-106472)
- Ibrutinib Impurity 150 (CAS 1839099-23-8)
- Ibrutinib Impurity 113 (CAS CATO-C4X-1064113)
- Ibrutinib Impurity N1 (CAS 1838132-94-7)
- Ibrutinib Impurity 171 (CAS CATO-C4X-1064171)
Recommended Standards
- Imatinib Impurity 67 (CAS 2031255-25-9)
- Ademetionine Impurity 2 (CAS CATO-C4X-21522)
- Adenosine Impurity 12 (CAS CATO-C4X-241912)
- Intermediate material 100066 (CAS CATO-CIM-100066)
- Fosfomycin Impurity 8 (CAS CATO-C4X-13168)
- Bromfenac Impurity 47 (CAS 241825-87-6)
- Rivaroxaban Impurity 186 (CAS CATO-C4X-1090186)
- 5-(2-Chloropyridin-3-yl)-3-(2-(difluoromethoxy)phenyl)-1,2,4-oxadiazole (CAS 1708250-85-4)
- 1-(2-Fluorobenzyl)-1h-pyrazole-5-carboxylic acid (CAS 1339906-44-3)
- (4-Amino-3-fluorophenyl)methanol (CAS 146019-45-6)
- 3-(1,1,1,3,3,3-Hexafluoropropan-2-yloxy)picolinaldehyde (CAS 1707391-77-2)
- 4-(3-Formyl-2,5-dimethyl-1h-pyrrol-1-yl)benzonitrile (CAS 501913-38-8)
- 1-(((6R,7R)-2-Carboxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)pyridin-1-ium chloride (CAS 65575-73-7)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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