Ibrutinib Impurity 187 CAS CATO-C4X-1064187
| CAS No. | CATO-C4X-1064187 |
| Molecular Formula | C47H48N12O3 |
| Molecular Weight | 828.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ibrutinib Impurity 187 (CAS CATO-C4X-1064187, C47H48N12O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ibrutinib Impurity 187 (C47H48N12O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C47H48N12O3 |
| Molecular Weight | 828.96 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 30.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 12 |
Related Ibrutinib Standards
- Ibrutinib Impurity 5 (CAS 1987905-93-0)
- Ibrutinib Impurity 101 (CAS CATO-C4X-1064101)
- Ibrutinib Impurity 178 (CAS CATO-C4X-1064178)
- Ibrutinib Impurity 30 (CAS CATO-C4X-106430)
- Ibrutinib Impurity 102 (CAS CATO-C4X-1064102)
- Ibrutinib Impurity 14 (CAS 2031255-23-7)
- Ibrutinib Impurity 161 (CAS CATO-C4X-1064161)
- Ibrutinib Impurity 18 (CAS 2417548-76-4)
Recommended Standards
- Mc-Val-Cit-PAB-B-ZZ6 (CAS CATO-C3D-262921)
- Cefpirome Impurity 7 (CAS CATO-C4X-12077)
- (4,4''-Di(10H-phenoxazin-10-yl)-[1,1':4',1''-terphenyl]-2',5'-diyl)bis(p-tolylmethanone) (CAS 1647121-46-7)
- Tos-PEG13-Boc (CAS 2820397-84-8)
- Atorvastatin Impurity 124 (CAS 666714-64-3)
- Resmetirom Impurity 47 (CAS CATO-C4X-291247)
- Acesulfame potassium EP Impurity A (CAS 5977-14-0)
- 4-(Difluoromethyl)-2-iodo-3-(trifluoromethoxy)-5-(trifluoromethyl)pyridine (CAS 1804920-61-3)
- 3-(Benzylthio)-1,2,4-triazin-5(4H)-one (CAS 90946-15-9)
- 4-(benzylamino)-6-(4-methoxyphenyl)-2-(4-pyridinyl)-5-pyrimidinecarbonitrile 400078-50-4 KS-000033IM (CAS 400078-50-4)
- 3-(2H-1,2,3-Triazol-2-yl)phenol (CAS 67149-24-0)
- (Butan-2-yl)[(2-methoxyphenyl)methyl]amine hydrochloride (CAS 1158320-22-9)
- 1-(4-Fluorophenyl)cyclopropan-1-ol (CAS 66267-05-8)
- D-Glu3-Tirzepatide (CAS CATO-CPTD788927)
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