Ibrutinib Impurity 18 CAS 2417548-76-4
| CAS No. | 2417548-76-4 |
| Molecular Formula | C50H48N12O4 |
| Molecular Weight | 880.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ibrutinib Impurity 18 (C50H48N12O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ibrutinib Impurity 18 (CAS 2417548-76-4) is a certified pharmaceutical impurity reference standard with the molecular formula C50H48N12O4 and a molecular weight of 880.99 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C50H48N12O4 |
| Molecular Weight | 880.99 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 33.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 12 |
Related Ibrutinib Standards
- Ibrutinib Impurity 102 (CAS CATO-C4X-1064102)
- Ibrutinib Impurity 14 (CAS 2031255-23-7)
- Ibrutinib Impurity 161 (CAS CATO-C4X-1064161)
- Ibrutinib Impurity 87 (CAS CATO-C4X-106487)
- Ibrutinib Impurity 88 (CAS 2417548-83-3)
- Ibrutinib Impurity 89 (CAS CATO-C4X-106489)
- Ibrutinib Impurity 90 (CAS 2417548-81-1)
- Ibrutinib Impurity N21 (CAS 2540665-98-1)
Recommended Standards
- (E)-6,6'-(Ethene-1,2-diyl)bis(3-((4-morpholino-6-(phenylamino)-1,3,5-triazin-2-yl)amino)benzenesulfonic acid) (CAS 32466-46-9)
- Cyclotetrakis (1,4-Butylene Terephthalate) (CAS 29278-72-6)
- Tris(triphenylphosphine)nickel chloride (CAS 15169-64-9)
- Crizotinib impurity 28 (CAS CATO-C4X-102528)
- Revefenacin Impurity 23 (CAS CATO-C4X-203123)
- ent-Cefradine EP Impurity B (CAS 26108-29-2)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Ethyl 5-(diethoxyphosphoryl)pentanoate (CAS 2323-74-2)
- Methyl 4-(azepan-4-ylamino)-6-((5-cyanopyrazin-2-yl)amino)nicotinate (CAS 1137476-98-2)
- 16:0 DGS (CAS 108032-13-9)
- (4-((2,2,2-Trifluoroethyl)amino)piperidin-4-yl)methanol (CAS 1250239-34-9)
- Indocyanine Green Impurity 61 (CAS CATO-C4X-250361)
- 4-Methoxy-2-((trimethylsilyl)oxy)pyrimidine (CAS 57098-88-1)
- Semaglutide Impurity 160 (x TFA Salt) (CAS CATO-C4X-2226160)
Why CATO?
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