Ibrutinib Impurity 65 CAS CATO-C4X-106465
| CAS No. | CATO-C4X-106465 |
| Molecular Formula | C29H30N6O4 |
| Molecular Weight | 526.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 65 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ibrutinib Impurity 65 (CAS CATO-C4X-106465) is a certified pharmaceutical impurity reference standard with the molecular formula C29H30N6O4 and a molecular weight of 526.59 g/mol.
Ibrutinib Impurity 65 (C29H30N6O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H30N6O4 |
| Molecular Weight | 526.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 189 (CAS CATO-C4X-1064189)
- Ibrutinib Impurity 26 (CAS CATO-C4X-106426)
- Ibrutinib Impurity 27 (CAS CATO-C4X-106427)
- Ibrutinib Impurity 188 (CAS CATO-C4X-1064188)
- Ibrutinib Impurity 141 (CAS CATO-C4X-1064141)
- Ibrutinib Impurity 162 (CAS CATO-C4X-1064162)
- Ibrutinib Impurity 168 (CAS CATO-C4X-1064168)
- Ibrutinib Impurity 17 (CAS CATO-C4X-106417)
Recommended Standards
- 2,6-Bis[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-4-[1-(phenylmethyl)-1H-1,2,3-triazol-4-yl]pyridine (CAS 1053181-13-7)
- Tepotinib impurity 8 (CAS CATO-C4X-33748)
- Boc-Ser(Val-Fmoc)-OH (CAS 944283-08-3)
- Desmosine (CAS 11003-57-9)
- Letermovir Impurity 4 (CAS CATO-CP155165)
- Ampicillin Impurity 68 (CAS CATO-C4X-144368)
- Afatinib Impurity 69 (CAS CATO-C4X-100669)
- 6-Amino-2,4-dichloronicotinonitrile (CAS 1589541-56-9)
- 4-chloro-1-isopropyl-6-sec-butyl-pyrazolo[3,4-d]pyrimidine (CAS 2868363-06-6)
- 5-Fluoro-2-(3-fluorophenoxy)aniline (CAS 937596-35-5)
- 4-(Benzo[d]thiazol-2-yl)butan-2-amine (CAS 933691-35-1)
- 5-(1-Methyl-2-pyrrolyl)isoxazole-3-carboxylic Acid (CAS 1326814-81-6)
- 2-(2,2-difluoroethyl)-2,3-dihydro-1H-isoindol-5-amine (CAS 1484193-33-0)
- Tau Peptide (294-305) (human) trifluoroacetate salt (CAS 1428135-29-8)
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