Erlotinib Impurity 46 CAS CATO-C4X-106946
| CAS No. | CATO-C4X-106946 |
| Molecular Formula | C20H25N3O4 |
| Molecular Weight | 369.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Erlotinib Impurity 46 (C20H25N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 369.42 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Erlotinib Impurity 46 (CAS CATO-C4X-106946) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25N3O4 and a molecular weight of 369.42 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25N3O4 |
| Molecular Weight | 369.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib impurity 128 (CAS 183321-84-8)
- Erlotinib impurity 134 (CAS CATO-C4X-1069134)
- Erlotinib Impurity 8 (CAS 183320-29-8)
- Erlotinib Impurity 92 (CAS 183321-86-0)
- Erlotinib Impurity 118 (CAS 1216420-11-9)
- Erlotinib Impurity 88 (CAS 18193-72-1)
- Erlotinib impurity 131 (CAS CATO-C4X-1069131)
Recommended Standards
- Trimetrexate (CAS 52128-35-5)
- Cefotaxime Impurity 49 (CAS 130468-09-6)
- Tivantinib (CAS 905854-02-6)
- Cefdinir Impurity 5 (CAS 178949-04-7)
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
- Ruxolitinib Impurity 127 (CAS CATO-C4X-2058127)
- Ipragliflozin Impurity 13 (CAS 1922933-61-6)
- Ethyl 3-[Hydroxy(4-nitrophenyl)methyl]isoxazole-4-carboxylate (CAS 2006277-72-9)
- 2-(1',2',3',4'-Tetrahydroxybutyl)quinoxaline (CAS 80840-09-1)
- 2-Piperazin-1-yl[1,3]thiazolo[5,4-b]pyridine (CAS 1095539-04-0)
- 2-(Methylthio)benzo[d]thiazole-5-carbonitrile (CAS 401567-16-6)
- 3,6-Dihydro-2H-thiopyran (CAS 40697-99-2)
- RN 486 (CAS 1242156-23-5)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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