Erlotinib Impurity 4 CAS CATO-C4X-10694
| CAS No. | CATO-C4X-10694 |
| Molecular Formula | C22H25N3O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Erlotinib Impurity 4 (CAS CATO-C4X-10694, C22H25N3O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Erlotinib Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 447.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Erlotinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25N3O5 HCl |
| Molecular Weight | 447.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
- Fluoxetine Impurity 25 (CAS 27152-62-1)
- Afobazole Impurity 1 (CAS 189638-30-0)
- Tofacitinib Impurity 106 (CAS 3430-27-1)
- tert-Butyl (R)-3-(2-(trifluoromethyl)phenyl)piperazine-1-carboxylate (CAS 1228553-47-6)
- Methyl 2-(4-amino-3-methylphenoxy)acetate (CAS 926200-79-5)
- 4-Fluoropiperidine-1-sulfonyl chloride (CAS 1224929-82-1)
- Benzeneacetonitrile, 5-iodo-2-methoxy- (CAS 2354747-40-1)
- Tert-butyl (4-aminocuban-1-yl)carbamate (CAS 1936223-92-5)
- 22658-92-0 (3S)-octan-3-ol DTXSID40426427 (CAS 22658-92-0)
- Liraglutide(5-31)TFA Salt (CAS CATO-C4X-19924)
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