Erlotinib Impurity 8 CAS 183320-29-8
| CAS No. | 183320-29-8 |
| Molecular Formula | C21H21N3O4 |
| Molecular Weight | 379.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Erlotinib Impurity 8.
As a process- or degradation-related impurity, Erlotinib Impurity 8 (CAS 183320-29-8, C21H21N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Erlotinib Impurity 8 (C21H21N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H21N3O4 |
| Molecular Weight | 379.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 92 (CAS 183321-86-0)
- Erlotinib Impurity 118 (CAS 1216420-11-9)
- Erlotinib impurity 134 (CAS CATO-C4X-1069134)
- Erlotinib impurity 131 (CAS CATO-C4X-1069131)
- Erlotinib Impurity 46 (CAS CATO-C4X-106946)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib metabolite M11 (CAS 882172-60-3)
- Erlotinib (CAS 183321-74-6)
Recommended Standards
- Valsartan Impurity 110 (CAS 1418314-03-0)
- (2S,4R)-1-(tert-butoxycarbonyl)-4-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid (2S,4R)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[[4-(trifluoromethyl)phenyl]methyl]-2-pyrrolidinecarboxylic acid (2S,4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxylic acid (2S,4R)-1-tert-butoxycarbonyl-4-[4-(trifluoromethyl)benzyl]proline (2S,4R)-1-tert-butoxycarbonyl-4-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxylic acid 957311-17-0 (CAS 957311-17-0)
- Gefitinib Impurity 90 (CAS CATO-C4X-111790)
- Z-His(Bzl)-OH (CAS 21929-66-8)
- Moxifloxacin Impurity 56 (CAS CATO-C4X-1074156)
- Apremilast Impurity 36 (CAS 608141-43-1)
- Vonoprazan Impurity 121 (CAS 13069-92-4)
- 1-Ethyl-2,3-dimethylimidazolium Tetrafluoroborate (CAS 307492-75-7)
- Samarium, (copper)[μ-[[3,3'-[1,2-cyclohexanediylbis[(nitrilo-κN)methylidyne]]bis[1,2-benzenediolato-κO1,κO2:κO2]](4-)]][4-(1,1-dimethylethyl)phenolato]- (CAS 937376-15-3)
- 2,5-Dichloro-N-(3-cyano-4-(methylsulfonyl)phenyl)benzamide (CAS 320421-60-1)
- (2S,5S)-1-(((2S,5S)-2,5-Dimethylpyrrolidin-1-yl)methylene)-2,5-dimethylpyrrolidin-1-ium tetrafluoroborate (CAS 1204324-13-9)
- (R)-1-(2-Aminoethyl)-N-(cyclopropylmethyl)pyrrolidin-3-amine (CAS 1354018-90-8)
- (E)-N-(4-Chlorophenyl)-N'-methyl-2-nitro-4-(trifluoromethyl)benzene-1-carboximidamide (CAS 303149-67-9)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com