Erlotinib Impurity 81 CAS CATO-C4X-106981
| CAS No. | CATO-C4X-106981 |
| Molecular Formula | C13H15ClN2O4 |
| Molecular Weight | 298.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Erlotinib Impurity 81 (CAS CATO-C4X-106981, C13H15ClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Erlotinib Impurity 81 (C13H15ClN2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Erlotinib Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H15ClN2O4 |
| Molecular Weight | 298.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Erlotinib Standards
- Erlotinib Impurity 58 (CAS CATO-C4X-106958)
- Erlotinib Impurity 59 (CAS CATO-C4X-106959)
- Erlotinib Impurity 82 (CAS CATO-C4X-106982)
- Erlotinib Impurity 118 (CAS 183322-16-9)
- Erlotinib Impurity 109 (CAS 476168-17-9)
- Erlotinib Impurity 30 (CAS CATO-C4X-106930)
- Erlotinib Impurity 31 (CAS CATO-C4X-106931)
- Erlotinib Impurity 32 (CAS 236750-65-5)
Recommended Standards
- Amlodipine Impurity 79 (CAS 3516-73-2)
- 7-Chloro-3-(2-oxo-2-phenyl-ethylidene)-3,4-dihydro-1H-quinoxalin-2-one 906439-35-8 (CAS 906439-35-8)
- Methotrexate Impurity 70 (CAS CATO-C4X-115470)
- 1845AE 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 372107-14-7 C16H11ClN2O2 (CAS 372107-14-7)
- Empagliflozin impurity 202 (CAS CATO-C4X-1065202)
- Quetiapine impurity 72 (CAS CATO-C4X-124472)
- Avanafil Impurity 130 (CAS CATO-C4X-1118130)
- 2-Bromo-4-difluoromethoxy-6-methylpyridine (CAS 1805526-37-7)
- 2-(Trifluoromethyl)thiazole-5-carboxylic Acid (CAS 1286734-84-6)
- (3-Bromophenyl)(3-fluorophenyl)methanol (CAS 1183311-32-1)
- 5-(Difluoromethyl)-3-methyl-1h-1,2,4-triazole (CAS 1094760-03-8)
- 1704097-61-9 3-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine (CAS 1704097-61-9)
- 8-Bromo-4-methoxyquinoline-2-carboxylic acid (CAS 1597297-10-3)
- Liraglutide-d8 Tetratrifluoroacetate (CAS 204656-20-2 (non-labelled, free base))
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