Erlotinib Impurity 89 CAS CATO-C4X-106989
| CAS No. | CATO-C4X-106989 |
| Molecular Formula | C8H6BrNO2 |
| Molecular Weight | 228.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Erlotinib Impurity 89.
Erlotinib Impurity 89 (CAS CATO-C4X-106989) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6BrNO2 and a molecular weight of 228.04 g/mol.
Erlotinib Impurity 89 (C8H6BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Erlotinib Impurity 89 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6BrNO2 |
| Molecular Weight | 228.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib Impurity 85 (CAS CATO-C4X-106985)
- Erlotinib Impurity 86 (CAS CATO-C4X-106986)
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 98 (CAS CATO-C4X-106998)
- Erlotinib Impurity 78 (CAS 174674-93-2)
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- Erlotinib Impurity 61 (CAS 20825-87-0)
Recommended Standards
- 8-Bromo-2H-1,4-benzoxazin-3(4H)-one (CAS 688363-48-6)
- 5-Amino-4-bromo-1,2-dihydro-3H-indazol-3-one (CAS 1000344-11-5)
- 7-Bromo-5-methylbenzo[d]oxazol-2(3H)-one (CAS 855273-64-2)
- 3-(5-Bromofuran-2-yl)-1h-pyrazol-5-amine (CAS 1028843-03-9)
- Abemaciclib Impurity 50 (CAS CATO-C4X-293750)
- Acetylcysteine Impurity 11 (CAS 79560-92-2)
- Pregabalin Impurity PD 0312237 & PD 0312236 Mixture (CAS CATO-C4X-13125)
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- 1H-benzo[g]indole-3-sulfonyl chloride (CAS 2231234-19-6)
- 1-Ethyl-6-(3-methoxyphenyl)-3-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 937598-74-8)
- 4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid Salt (CAS 359436-59-2)
- (2Z)-2-(4-chlorophenyl)-3-[4-(2,4-dichlorobenzoyl)-1-methyl-1H-pyrrol-2-yl]prop-2-enenitrile 338786-73-5 6F-061 (CAS 338786-73-5)
- 7-Fluorobenzo[c][1,2]oxaborole-1,6(3H)-diol (CAS 1629141-26-9)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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