Erlotinib Impurity 78 CAS 174674-93-2
| CAS No. | 174674-93-2 |
| Molecular Formula | C11H14O4 |
| Molecular Weight | 210.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Erlotinib Impurity 78 (CAS 174674-93-2), a pharmacopoeial impurity reference standard (molecular formula C11H14O4, MW 210.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Erlotinib Impurity 78 (C11H14O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 210.23 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H14O4 |
| Molecular Weight | 210.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
Related Erlotinib Standards
- Erlotinib Impurity 79 (CAS 382150-30-3)
- Erlotinib Impurity 61 (CAS 20825-87-0)
- Erlotinib Impurity 105 (CAS 33432-52-9)
- Erlotinib impurity 130 (CAS 585-79-5)
- Erlotinib Impurity 87 (CAS CATO-C4X-106987)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Impurity 112 (CAS 555-68-0)
- Erlotinib Impurity 51 (CAS 115665-66-2)
Recommended Standards
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