Tenofovir disoproxil Impurity 127 CAS CATO-C4X-1076127
| CAS No. | CATO-C4X-1076127 |
| Molecular Formula | C32H52N5O18P |
| Molecular Weight | 825.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tenofovir disoproxil Impurity 127 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tenofovir disoproxil Impurity 127 (CAS CATO-C4X-1076127, C32H52N5O18P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tenofovir disoproxil Impurity 127 (C32H52N5O18P) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C32H52N5O18P |
| Molecular Weight | 825.75 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir disoproxil impurity 123 (CAS 1962114-92-6)
- Tenofovir disoproxil Impurity 129 (CAS CATO-C4X-1076129)
- Tenofovir Impurity 83 (CAS CATO-C4X-107683)
- Tenofovir dipivuroxime enrutabine adduct (CAS 1962114-98-2)
- Tenofovir disoproxil Impurity 131 (CAS CATO-C4X-1076131)
- Tenofovir disoproxil Impurity 119 (CAS CATO-C4X-1076119)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 118 (CAS CATO-C4X-1076118)
Recommended Standards
- 9-(2-Carboxyphenyl)-2,7-dichloro-4,5-bis[(2-picolyl)(pyrazin-2-ylmethyl)aminomethyl]-6-hydoxy-3-xanthanone ZPP1 (CAS 1084898-23-6)
- Euojaponine D (CAS 128397-42-2)
- S-(2-(3-((2R)-4-(((((((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) 2-hydroxyethanethioate (CAS 1264-31-9)
- Raloxifene 6,4'-Bis-β-D-glucuronide (CAS 182507-20-6)
- Troxipide Impurity 10 (CAS CATO-C4X-214810)
- Dabigatran Impurity 93 (CAS 7452-59-7)
- Finerenone Impurity 139 (CAS CATO-C4X-2880139)
- 3-Iodo-4-methoxy-2-phenyl-4,5,6,7-tetrahydrobenzofuran (CAS 866558-05-6)
- 1-(6-Bromopyridin-2-yl)-2-methylpropan-2-ol (CAS 955369-59-2)
- 1-Ethyl-4-(2-(3-nitrophenyl)hydrazono)piperidine (CAS 481697-90-9)
- n-(4-Ethoxy-3-methoxyphenyl)pivalamide (CAS 923679-54-3)
- 5-Chloro-3-methylbenzo[d]thiazol-2(3H)-one (CAS 2786-28-9)
- 2-{[(5-methyl-1,2-oxazol-3-yl)amino]methyl}phenol (CAS 298216-14-5)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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