Tofacitinib Impurity 175 CAS CATO-C4X-1079175
| CAS No. | CATO-C4X-1079175 |
| Molecular Formula | C16H20N6O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity 175 (CAS CATO-C4X-1079175) is a certified pharmaceutical impurity reference standard with the molecular formula C16H20N6OC6H8O7 and a molecular weight of 504.50 g/mol.
Structurally, Tofacitinib Impurity 175 (C16H20N6OC6H8O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 504.50 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 175 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N6O C6H8O7 |
| Molecular Weight | 504.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Tryptophan EP Impurity H (CAS 6052-68-2)
- Budesonide Impurity 33 (CAS 131918-73-5)
- Finerenone Impurity 219 (CAS CATO-C4X-2880219)
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- 2-(6-Chloropyridin-3-yl)-1,3-diazaspiro[4.4]Non-1-en-4-one (CAS 2306264-58-2)
- 4-[(2-methoxy-5-methylphenyl)amino]butanoic acid (CAS 1016735-33-3)
- 2-Bromo-6-(difluoromethoxy)naphthalene (CAS 244103-47-7)
- (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-fluorobenzyl)propanoic acid (CAS 1260609-18-4)
- (6-Bromo-3-methoxy-2-methylphenyl)methanol (CAS 110451-91-7)
- endo-Arg30-Semaglutide (CAS CATO-C4X-2226281)
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