Tofacitinib Impurity 177 CAS CATO-C4X-1079177
| CAS No. | CATO-C4X-1079177 |
| Molecular Formula | C16H19N7O2 |
| Molecular Weight | 341.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Tofacitinib Impurity 177 (CAS CATO-C4X-1079177) is a certified pharmaceutical impurity reference standard with the molecular formula C16H19N7O2 and a molecular weight of 341.37 g/mol.
The molecular framework of Tofacitinib Impurity 177 (C16H19N7O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Tofacitinib Impurity 177 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19N7O2 |
| Molecular Weight | 341.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Tofacitinib Standards
- Tofacitinib Impurity 178 (CAS 934524-10-4)
- Tofacitinib Impurity 209 (CAS CATO-C4X-1079209)
- Tofacitinib Impurity 239 (CAS CATO-C4X-1079239)
- Tofacitinib Impurity 238 (CAS CATO-C4X-1079238)
- Tofacitinib Impurity 65 (CAS CATO-C4X-107965)
- Tofacitinib Impurity 58 (CAS CATO-C4X-107958)
- Tofacitinib Impurity 249 (CAS CATO-C4X-1079249)
- Tofacitinib Impurity 226 (CAS 2101951-13-5)
Recommended Standards
- 596-43-0 Benzene, 1,1',1''-(bromomethylidyne)tris- 2-Bromo-1,1,1-triphenylethane Methane, bromotriphenyl- 4-05-00-02500 (Beilstein Handbook Reference) AI3-51274 BRN 1878494 Bromotriphenylmethane EINECS 209-884-4 NSC 66464 Triphenylmethyl bromide Trityl bromide (CAS 596-43-0)
- Pimavanserin Impurity 5 (CAS 932724-63-5)
- Nicotine-d (CAS 329002-74-6)
- Ethyl 2-(methylthio)-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate (CAS 100426-81-1)
- Dimetindene EP Impurity C (CAS 92726-29-9)
- Edaravone impurity 35 (Mixture of Enantiomers) (CAS CATO-C4X-106235)
- Upadacitinib Impurity 154 (CAS CATO-C4X-2405154)
- 2-[(2,2,2-trifluoroethyl)carbamoyl]acetic acid (CAS 1248985-24-1)
- 2-(4-(Difluoromethyl)-3-(trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1804692-94-1)
- N,N′,2-Trimethylimidodicarbonic diamide (CAS 816-00-2)
- (1-(3-Chloro-4-fluorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl)methanol (CAS 618444-43-2)
- Triethylsulfonium (CAS 29245-61-2)
- 3-Fluoro-N-(piperidin-4-yl)benzamide (CAS 886504-86-5)
- CBP501 Affinity Peptide trifluoroacetate salt (CAS 1351804-17-5)
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