Tofacitinib Impurity 23 DiHCl CAS CATO-C4X-107923
| CAS No. | CATO-C4X-107923 |
| Molecular Formula | C15H23N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 309.84 g/mol gives Tofacitinib Impurity 23 DiHCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tofacitinib Impurity 23 DiHCl (CAS CATO-C4X-107923, C15H23N5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H23N5HCl, Tofacitinib Impurity 23 DiHCl contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 309.84 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H23N5 2*HCl |
| Molecular Weight | 309.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Mirogabalin Impurity 54 (CAS 3003799-01-4)
- Selumetinib Impurity 5 (CAS CATO-C4X-30535)
- Desmopressin EP Impurity G (CAS CATO-C4X-23652)
- Potassium [2,2'-biquinoline]-4,4'-dicarboxylate hydrate (CAS 1268237-71-3)
- 4-(((3-Methoxyphenyl)sulfonamido)methyl)benzoic acid (CAS 727689-56-7)
- n-(4-Morpholinophenyl)-2-(4-phenylpiperazin-1-yl)acetamide (CAS 763125-30-0)
- 2-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-sulfonyl chloride (CAS 1799541-52-8)
- (2,3-Dihydro-1H-inden-5-yl)methanamine hydrochloride (CAS 721968-63-4)
- Ethyl 1-((4-methoxyphenyl)carbamoyl)-4,6-dioxo-5-(3-(trifluoromethyl)phenyl)-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate (CAS 318237-90-0)
- Hexapeptide-10 (CAS 146439-94-3)
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