Tofacitinib Impurity 237 CAS CATO-C4X-1079237
| CAS No. | CATO-C4X-1079237 |
| Molecular Formula | C15H17N7O |
| Molecular Weight | 311.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib Impurity 237 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tofacitinib Impurity 237 (CAS CATO-C4X-1079237, C15H17N7O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tofacitinib Impurity 237 (C15H17N7O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17N7O |
| Molecular Weight | 311.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Tofacitinib Standards
- Tofacitinib Impurity 236 (CAS CATO-C4X-1079236)
- (Rac)-Tofacitinib (CAS 1259404-17-5)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 2 (CAS 1092578-48-7)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 245 (CAS CATO-C4X-1079245)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
- Tofacitinib Impurity 34 (Mixture of Diastereomers) (CAS 344418-92-4)
Recommended Standards
- Oxcarbazepine Impurity 38 (CAS CATO-C4X-116438)
- N-benzyl-5-(hydroxyimino)-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide (CAS 940242-19-3)
- Imazaquin (CAS 81335-37-7)
- N,1-Diethyl-2-imino-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 371232-92-7)
- Fluralaner impurity 30 (CAS CATO-C4X-218030)
- Brivaracetam Impurity 198 (CAS CATO-C4X-2007198)
- Pravastatin EP Impurity C Sodium Salt (CAS 159225-12-4)
- (5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazin-6-yl)methanol (CAS 1628636-87-2)
- 1-(2-hydroxyethyl)azepan-2-one (CAS 45889-43-8)
- 4-Bromo-5-(trifluoromethyl)pyridin-2-ol (CAS 1227494-05-4)
- Spiro[5.5]undecan-2-amine hydrochloride (CAS 62439-54-7)
- 2-{[2-(3,5-dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]sulfanyl}-4,6-bis(thiophen-2-yl)pyridine-3-carbonitrile (CAS 311810-06-7)
- 5-((5-Amino-4-((3-aminopropyl)amino)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CAS 1137476-38-0)
- Peptide 74 (H-8545.0500) (CAS 132116-39-3)
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