Tofacitinib Impurity 25 CAS CATO-C4X-107925
| CAS No. | CATO-C4X-107925 |
| Molecular Formula | C28H34N4OS |
| Molecular Weight | 474.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 25.
Tofacitinib Impurity 25 (CAS CATO-C4X-107925) is a certified pharmaceutical impurity reference standard with the molecular formula C28H34N4OS and a molecular weight of 474.66 g/mol.
Tofacitinib Impurity 25 (C28H34N4OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage. Its physicochemical properties are representative of its class; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H34N4OS |
| Molecular Weight | 474.66 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 78 (CAS CATO-C4X-107978)
- Tofacitinib Impurity 45 (CAS CATO-C4X-107945)
- Tofacitinib Impurity 35 (CAS CATO-C4X-107935)
- Tofacitinib Impurity 36 (CAS CATO-C4X-107936)
- Tofacitinib Impurity 56 (CAS 923036-30-0)
- Tofacitinib Impurity 64 (CAS 2504210-40-4)
- Tofacitinib Impurity 103 (CAS CATO-C4X-1079103)
- Tofacitinib Impurity 240 (CAS CATO-C4X-1079240)
Recommended Standards
- (E)-4-Chloro-3-(1,2-dibromodec-1-en-1-yl)-6-methylcinnoline (CAS 1204213-42-2)
- methyl (4R)-4-[(3R,5S,6S,8S,9S,10S,13R,14S,17R)-3-acetyloxy-6-ethyl-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate (CAS 1831863-19-4)
- Dienochlor (CAS 2227-17-0)
- methyl (4R)-4-[(3R,5S,6R,8S,9S,10S,13R,14S,17R)-3-acetyloxy-6-ethyl-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate (CAS 1953137-50-2)
- Finerenone Impurity 103 (CAS CATO-C4X-2880103)
- Hydrochlorothiazide Impurity 9 (CAS 2089381-36-0)
- Lurasidone Impurity 60 (CAS 1807983-61-4)
- (S)-4-Aminopentan-1-ol (CAS 1630497-31-2)
- 5-(Hydroxymethyl)pyrazine-2-carboxamide (CAS 412277-94-2)
- Ethyl 2-chloro-5-nitronicotinate (CAS 151322-83-7)
- (E)-1-Methyl-4-(6-methylhepta-2,5-dien-2-yl)-7-oxabicyclo[4.1.0]heptane (CAS 223753-47-7)
- 5,5'-Dibromo-2,2'-bipyrimidine (CAS 400859-09-8)
- (2E)-1-{[1,1'-Biphenyl]-4-yl}-3-(3-methoxyphenyl)prop-2-en-1-one (CAS 1427577-87-4)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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