Tofacitinib Impurity 92 CAS CATO-C4X-107992
| CAS No. | CATO-C4X-107992 |
| Molecular Formula | C26H28N8 |
| Molecular Weight | 452.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 92 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tofacitinib Impurity 92 (CAS CATO-C4X-107992, C26H28N8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C26H28N8, Tofacitinib Impurity 92 contains a nitrogen-containing heterocyclic scaffold, a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 452.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H28N8 |
| Molecular Weight | 452.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related Tofacitinib Standards
- Tofacitinib Impurity 103 (CAS CATO-C4X-1079103)
- Tofacitinib Impurity 240 (CAS CATO-C4X-1079240)
- Tofacitinib Impurity 80 (CAS CATO-C4X-107980)
- Tofacitinib Impurity 89 (CAS CATO-C4X-107989)
- Tofacitinib Impurity 45 (CAS CATO-C4X-107945)
- Tofacitinib Impurity 109 (CAS CATO-C4X-1079109)
- Tofacitinib Impurity 78 (CAS CATO-C4X-107978)
- Tofacitinib Impurity 211 (CAS CATO-C4X-1079211)
Recommended Standards
- N-[(1S)-1-(Cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl] (CAS 2103278-86-8)
- Nor Acetildenafil (CAS 949091-38-7)
- Hoechst 33342 (CAS 23491-52-3)
- Fondenafil (CAS 944241-52-5)
- Moxifloxacin Impurity 85 (CAS CATO-C4X-107485)
- Axitinib Impurity 35 (CAS 1443118-71-5)
- Benzylpenicillin Impurity 11 (CAS 118-53-6)
- 1-(5-Methyl-1-phenyl-1h-pyrazol-4-yl)ethan-1-amine (CAS 956757-13-4)
- Xanomeline impurity 61 (CAS CATO-C4X-330161)
- 5,7-Dichloro-2H-benzo[b][1,4]thiazin-3(4H)-one (CAS 100831-31-0)
- 4-(1,3-Thiazol-2-yl)-1,3-thiazol-2-amine (CAS 7520-81-2)
- tert-butyl ((1R,2R)-2-((3-fluorobenzyl)oxy)cyclohexyl)carbamate (CAS 2126143-16-4)
- 1-Benzyl-3-cyclohexylthiourea (CAS 78080-33-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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