Tofacitinib Impurity 90 CAS CATO-C4X-107990
| CAS No. | CATO-C4X-107990 |
| Molecular Formula | C19H22N8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tofacitinib Impurity 90 (CAS CATO-C4X-107990, C19H22N8HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tofacitinib Impurity 90 (C19H22N8HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 398.90 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 90 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22N8 HCl |
| Molecular Weight | 398.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Olodaterol Impurity 31 (CAS CATO-C4X-194331)
- Ceftaroline Fosamil Impurity C2 (CAS 1277090-04-6)
- Roxithromycin Impurity 17 (CAS 74498-88-7)
- 2-Bromo-4-fluoro-5-nitroaniline (CAS 346433-97-4)
- O1-tert-butyl O2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate (CAS 121148-00-3)
- 3-(4-acetyl-5-methyl-2-furyl)propanoic acid (CAS 858247-32-2)
- 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic Acid (CAS 124243-00-1)
- 2-(2,3-Dichlorophenyl)-2-(piperidin-1-yl)acetic acid (CAS 1218310-40-7)
- Tert-butyl 3,6-diazabicyclo[3.1.0]Hexane-6-carboxylate (CAS 1262407-15-7)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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