Tadalafil Impurity 174 CAS CATO-C4X-1087174
| CAS No. | CATO-C4X-1087174 |
| Molecular Formula | C16H18Cl2N2O4 |
| Molecular Weight | 373.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tadalafil Impurity 174.
CATO supplies Tadalafil Impurity 174 (CAS CATO-C4X-1087174), a pharmacopoeial impurity reference standard (molecular formula C16H18Cl2N2O4, MW 373.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Tadalafil Impurity 174 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 373.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tadalafil Impurity 174 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18Cl2N2O4 |
| Molecular Weight | 373.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 138 (CAS CATO-C4X-1087138)
- Tadalafil Impurity N6 (CAS 479545-76-1)
- Tadalafil Impurity 81 (CAS CATO-C4X-108781)
- Tadalafil Impurity 46 (CAS 1598416-07-9)
- Tadalafil impurity 127 (CAS CATO-C4X-1087127)
- Tadalafil impurity 128 (CAS CATO-C4X-1087128)
- Tadalafil Impurity 172 (CAS CATO-C4X-1087172)
- Tadalafil Impurity 152 (CAS CATO-C4X-1087152)
Recommended Standards
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- Lasmiditan Impurity 11 (CAS CATO-C4X-247811)
- Thioctic Acid Impurity 10 (CAS CATO-C4X-151810)
- Erlotinib Impurity 15 (CAS CATO-C4X-106915)
- Ethyl 8-hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylate (CAS 134970-49-3)
- 2-(Butylthio)pyrimidin-4(1H)-one (CAS 54774-97-9)
- 1-amino-3,3-difluoro-cyclobutanecarboxylic acid (CAS 1225532-86-4)
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- 3-(3-Ethoxy-4-hydroxybenzylidene)-5-(4-methoxyphenyl)furan-2(3H)-one (CAS 6621-91-6)
- 5-Chloro-2-thienylmagnesium bromide, 0.25M 2-MeTHF (CAS 111762-30-2)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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