Tadalafil Impurity 81 CAS CATO-C4X-108781
| CAS No. | CATO-C4X-108781 |
| Molecular Formula | C21H19N3O4 |
| Molecular Weight | 377.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tadalafil Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tadalafil Impurity 81 (CAS CATO-C4X-108781, C21H19N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Tadalafil Impurity 81 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 377.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H19N3O4 |
| Molecular Weight | 377.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 46 (CAS 1598416-07-9)
- Tadalafil Impurity N6 (CAS 479545-76-1)
- Tadalafil impurity 127 (CAS CATO-C4X-1087127)
- Tadalafil impurity 128 (CAS CATO-C4X-1087128)
- Tadalafil Impurity 174 (CAS CATO-C4X-1087174)
- Tadalafil Impurity 138 (CAS CATO-C4X-1087138)
- Tadalafil Impurity 172 (CAS CATO-C4X-1087172)
- Tadalafil (CAS 171596-29-5)
Recommended Standards
- Desmethylene Tadalafil (CAS 171489-03-5)
- Enalapril Impurity 35 (CAS CATO-C4X-133435)
- Vonoprazan Impurity 224 (CAS CATO-C4X-1020224)
- N-nitroso-enalaprilat (CAS CATO-C4X-133440)
- Palbociclib Impurity N82 (CAS 571190-22-2)
- Pitolisant Impurity 44 (CAS 50529-73-2)
- Sunitinib Impurity 52 (CAS 2199-59-9)
- (S)-1-((S)-2-Ethyl-1,3,2-dioxaborolan-4-yl)ethane-1,2-diyl diacetate (CAS 74793-27-4)
- Scopolamine impurity 24 (CAS CATO-C4X-195824)
- 2-(Pyridin-2-yl)benzonitrile (CAS 74764-51-5)
- 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-methyl-1H-pyrazol-5-amine (CAS 1644602-69-6)
- N-(1,3-dihydroxypropan-2-yl)picolinamide (CAS 1490857-29-8)
- Yttrium chloride monohydrate (CAS 13470-35-4)
- Peptide Impurity 11 X TFA Salt (CAS CATO-CPTD788811)
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