Tadalafil Impurity 51 CAS CATO-C4X-108751
| CAS No. | CATO-C4X-108751 |
| Molecular Formula | C22H17Cl3N2O5 |
| Molecular Weight | 495.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tadalafil Impurity 51 (CAS CATO-C4X-108751), a pharmacopoeial impurity reference standard (molecular formula C22H17Cl3N2O5, MW 495.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Tadalafil Impurity 51 (C22H17Cl3N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Tadalafil Impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H17Cl3N2O5 |
| Molecular Weight | 495.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 150 (CAS 2361527-35-5)
- Tadalafil Impurity 108 (CAS CATO-C4X-1087108)
- Tadalafil Impurity 69 (CAS CATO-C4X-108769)
- Tadalafil Impurity 68 (CAS CATO-C4X-108768)
- Tadalafil Impurity 151 (CAS 2520114-64-9)
- Tadalafil Impurity 77 (CAS 2064212-00-4)
- Tadalafil Impurity 168 (CAS CATO-C4X-1087168)
- Tadalafil Impurity 109 (CAS CATO-C4X-1087109)
Recommended Standards
- NVP-BEZ 235 (CAS 915019-65-7)
- ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-bis((tert-butyldimethylsilyl)oxy)tetrahydrofuran-2-yl)methanol (CAS 69504-15-0)
- 171973-69-6 2-(Acetylamino)-2-deoxy-3-O-acetyl-4,6-O-benzylidene-|A-D-galactopyranose Trichloroacetimidate 2-(Acetylamino)-2-deoxy-4,6-O-(phenylmethylene)-|A-D-galactopyranose 3-Acetate 1-(2,2,2-Trichloroethanimidate) (CAS 171973-69-6)
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- 1-((5-Chloroquinolin-8-yl)oxy)-2-oxopropyl acetate (CAS 146893-26-7)
- 1-(3-Chloro-5-fluorophenyl)propan-1-one (CAS 886496-66-8)
- 4',5'-Dichloro-3',6'-dihydroxy-2',7'-dimethoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid (CAS 82855-39-8)
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- 4-(6-Hydroxy-1H-indazol-3-yl)benzene-1,3-diol (CAS 117767-16-5)
- Renin Inhibitor Peptide (CAS 50410-01-0)
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