Tadalafil Impurity 64 CAS CATO-C4X-108764
| CAS No. | CATO-C4X-108764 |
| Molecular Formula | C22H17N3O5 |
| Molecular Weight | 403.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tadalafil Impurity 64 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tadalafil Impurity 64 (CAS CATO-C4X-108764, C22H17N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tadalafil Impurity 64 (C22H17N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 403.39 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17N3O5 |
| Molecular Weight | 403.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 166 (CAS CATO-C4X-1087166)
- Tadalafil Impurity 63 (CAS 1346602-17-2)
- Tadalafil EP Impurity G (CAS 2520114-46-7)
- Tadalafil Impurity 90 (CAS 1978323-00-0)
- Tadalafil Impurity 141 (CAS 477970-21-1)
- Tadalafil Impurity 22 (CAS 1609405-34-6)
- Tadalafil Impurity 176 (CAS CATO-C4X-1087176)
- Tadalafil Impurity N1 (CAS 1220393-12-3)
Recommended Standards
- Z-Gly-Pro-OSu (C-1885.0005) (CAS 38417-02-6)
- Nilvadipine Impurity 1 (CAS 1452166-70-9)
- Z-Gly-Gly-His-OH (CAS 52396-73-3)
- Azoxystrobin (CAS 131860-33-8)
- Cefminox Impurity 39 (CAS CATO-C4X-192639)
- Gadobenate Dimeglumine Impurity 2 (CAS 71231-87-3)
- Enzalutamide Impurity 67 (CAS CATO-C4X-101667)
- 4-Methyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)aniline (CAS 1454653-68-9)
- 6-bromo-3,4-dihydro-2H-1-benzothiopyran (CAS 109209-87-2)
- Diethyl 2-chloromalonate (CAS 14064-10-9)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-nitropyridine (CAS 1806072-39-8)
- 3-Cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile (CAS 1153949-61-1)
- N-(prop-2-yn-1-yl)cyclohex-3-ene-1-carboxamide (CAS 1090994-99-2)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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