Tadalafil Impurity 166 CAS CATO-C4X-1087166
| CAS No. | CATO-C4X-1087166 |
| Molecular Formula | C22H17N3O5 |
| Molecular Weight | 403.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Tadalafil Impurity 166 (CAS CATO-C4X-1087166) is a certified pharmaceutical impurity reference standard with the molecular formula C22H17N3O5 and a molecular weight of 403.39 g/mol.
The molecular framework of Tadalafil Impurity 166 (C22H17N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17N3O5 |
| Molecular Weight | 403.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 63 (CAS 1346602-17-2)
- Tadalafil Impurity 64 (CAS CATO-C4X-108764)
- Tadalafil EP Impurity G (CAS 2520114-46-7)
- Tadalafil Impurity 90 (CAS 1978323-00-0)
- Tadalafil Impurity 141 (CAS 477970-21-1)
- Tadalafil Impurity 22 (CAS 1609405-34-6)
- Tadalafil Impurity 176 (CAS CATO-C4X-1087176)
- Tadalafil Impurity N1 (CAS 1220393-12-3)
Recommended Standards
- Z-Gly-Pro-OSu (C-1885.0005) (CAS 38417-02-6)
- Z-Gly-Gly-His-OH (CAS 52396-73-3)
- 6-Benzylaminopurine 9-(b-D-glucoside) (CAS 4294-17-1)
- 3-(2,6-Difluorophenyl)-4-((3-(trifluoromethyl)phenoxy)methyl)thiazole-2(3H)-thione (CAS 866153-95-9)
- Cabazitaxel Impurity 1 (CAS 183133-97-3)
- Pranoprofen Impurity N2 (CAS 6722-09-4)
- Letrozole Impurity 7 (CAS 1644566-39-1)
- Ceforanide (CAS 60925-61-3)
- N-(4-(Furan-2-yl)butan-2-yl)-1-phenyl-5-(pyridin-2-yl)-1H-1,2,3-triazole-4-carboxamide (CAS 1396854-66-2)
- 3-(2,2,2-Trifluoro-n-isopropylacetamido)propanoic acid (CAS 1178427-96-7)
- 5-(3-Amino-1h-1,2,4-triazol-1-yl)-2,2-dimethylpentanenitrile (CAS 1490906-84-7)
- 6,7-Dimethoxynaphthalen-1-ol (CAS 135678-71-6)
- 4,4,4-Trifluoro-3-(trifluoromethyl)butane-1,3-diol (CAS 21379-33-9)
- [Formaldehyde Schiff-base]-Semaglutide Impurity 136 X TFA Salt (CAS CATO-C4X-2226136)
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