Apixaban Impurity 74 CAS CATO-C4X-108874
| CAS No. | CATO-C4X-108874 |
| Molecular Formula | C25H33Cl2N3O4 |
| Molecular Weight | 510.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity 74 (CAS CATO-C4X-108874) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33Cl2N3O4 and a molecular weight of 510.45 g/mol.
The molecular framework of Apixaban Impurity 74 (C25H33Cl2N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H33Cl2N3O4 |
| Molecular Weight | 510.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Apixaban Standards
- Apixaban Impurity 53 (CAS CATO-C4X-108853)
- Apixaban Impurity 174 (CAS CATO-C4X-1088174)
- Apixaban Impurity 60 (CAS CATO-C4X-108860)
- Apixaban Impurity 136 (CAS CATO-C4X-1088136)
- Apixaban Impurity 132 (CAS 3094994-84-7)
- Apixaban Impurity 135 (CAS CATO-C4X-1088135)
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Apixaban Impurity 139 (CAS CATO-C4X-1088139)
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- potassium 2-((difluoromethyl)thio)acetate (CAS 1797117-16-8)
- 6,7-Dichloro-4-(4-chlorophenyl)-2-(2,4-dichloro-5-methoxyphenyl)-1,2-dihydrophthalazin-1-one (CAS 400087-13-0)
- 2-(4-(Methylsulfonyl)piperazin-1-yl)thiazol-4-amine (CAS 1023815-33-9)
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