Apixaban Impurity 132 CAS 3094994-84-7
| CAS No. | 3094994-84-7 |
| Molecular Formula | C25H26N6O6 |
| Molecular Weight | 506.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apixaban Impurity 132 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Apixaban Impurity 132 (CAS 3094994-84-7, C25H26N6O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Apixaban Impurity 132 (C25H26N6O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 506.51 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 132 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H26N6O6 |
| Molecular Weight | 506.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 6 |
Related Apixaban Standards
- Apixaban Impurity 135 (CAS CATO-C4X-1088135)
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Apixaban Impurity 136 (CAS CATO-C4X-1088136)
- Apixaban Impurity 139 (CAS CATO-C4X-1088139)
- Apixaban Impurity 74 (CAS CATO-C4X-108874)
- Apixaban Impurity 152 (CAS CATO-C4X-1088152)
- Apixaban Impurity 175 (CAS 1686149-80-3)
- Apixaban Impurity 176 (CAS 2098457-95-3)
Recommended Standards
- N,N'-(4,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,5-diyl)bis(4-methylbenzamide) (CAS 84559-87-5)
- Thalidomide-O-amido-PEG3-C2-NH2 (CAS 1957236-20-2)
- Cefamandole Oxide Impurity 15 (CAS CATO-C4X-122115)
- 2-[N-[2-(Fmoc-amino)ethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido]acetic Acid (CAS 169396-92-3)
- Delafloxacin Impurity 22 (CAS CATO-C4X-263722)
- Abiraterone Impurity 9 (CAS 566-19-8)
- Travoprost Impurity 43 (CAS CATO-C4X-192543)
- (S)-1-tert-Butyl 2-ethyl 4-methylenepyrrolidine-1,2-dicarboxylate (CAS 453524-59-9)
- 3-(Morpholin-2-yl)phenol (CAS 46179-92-4)
- Elagolix Impurity 13 (CAS CATO-C4X-206813)
- Ammonium dibenzyl phosphate (CAS 1277151-44-6)
- 1-(Difluoromethoxy)naphthalene-2-carboxylic acid (CAS 1261729-87-6)
- 2,4-Difluoro-2-(3-pyrrolinomethyl) benzophenone (CAS 898763-80-9)
- HIV (gp120) Antigenic Peptide (H-2982.0500) (CAS 198636-94-1)
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