Ticagrelor Impurity 81 CAS CATO-C4X-109381
| CAS No. | CATO-C4X-109381 |
| Molecular Formula | C16H17ClF2N4S |
| Molecular Weight | 370.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ticagrelor Impurity 81 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ticagrelor Impurity 81 (CAS CATO-C4X-109381) is a certified pharmaceutical impurity reference standard with the molecular formula C16H17ClF2N4S and a molecular weight of 370.85 g/mol.
Ticagrelor Impurity 81 (C16H17ClF2N4S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ticagrelor Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H17ClF2N4S |
| Molecular Weight | 370.85 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor EP Impurity A (CAS 1251765-07-7)
- Ticagrelor Impurity 9 (CAS 1445580-43-7)
- Ticagrelor Impurity 82 (CAS 220241-60-1)
- Ticagrelor Impurity 10 (CAS 1402150-32-6)
- Ticagrelor Impurity 192 (CAS 1628472-93-4)
- Ticagrelor impurity 169 (CAS CATO-C4X-1093169)
- Ticagrelor Impurity 111 (CAS 220352-29-4)
- Ticagrelor Impurity 67 (CAS CATO-C4X-109367)
Recommended Standards
- (3E)-3-{[(4-chlorophenyl)methoxy]imino}-1-(2-phenyl-1,3-thiazol-5-yl)propan-1-one 338414-38-3 3M-044 (CAS 338414-38-3)
- 4-((2-Chloro-3-phenylallylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497920-22-6)
- Ethyl 4-((4-chlorophenyl)thio)-2-phenylpyrimidine-5-carboxylate (CAS 477854-48-1)
- 4-((3-Allyl-2-hydroxybenzylidene)amino)-3-(2-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-30-7)
- Prednisone Impurity 13 (CAS 97830-94-9)
- Dexpanthenol impurity 9 (CAS CATO-C4X-16139)
- Salbutamol Impurity 45 (CAS CATO-C4X-117645)
- 2,3-Dimethoxybenzaldehyde-d (CAS 105258-77-3)
- Crotonoside (CAS 1818-71-9)
- 4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde (CAS 1357098-11-3)
- N-Boc-4,4-difluoro-L-prolinamide (CAS 426844-50-0)
- 2-(Pyrimidin-2-yl)acetamide (CAS 1220039-43-9)
- propionic acid (CAS 79-09-4)
- D-Thr5-Tirzepatide (CAS CATO-CPTD788926)
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