Ezetimibe Impurity 43 CAS CATO-C4X-109843
| CAS No. | CATO-C4X-109843 |
| Molecular Formula | C24H23F2NO3 |
| Molecular Weight | 411.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 411.44 g/mol gives Ezetimibe Impurity 43 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ezetimibe Impurity 43 (CAS CATO-C4X-109843, C24H23F2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ezetimibe Impurity 43 (C24H23F2NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ezetimibe Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H23F2NO3 |
| Molecular Weight | 411.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 13(Open Ring Impurity) (CAS 1197811-72-5)
- Ezetimibe Impurity 61 (CAS CATO-C4X-109861)
- Ezetimibe Impurity 94 (CAS CATO-C4X-109894)
- Ezetimibe Impurity 411 (CAS CATO-C4X-183738)
- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
Recommended Standards
- N-(5,6-Dimethyl-1-propyl-1H-1,3-benzodiazol-4-yl)-3-(trifluoromethyl)benzene-1-sulfonamide (CAS 338423-77-1)
- N-(4-Fluorophenyl)-3-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)thiophene-2-carboxamide (CAS 250714-43-3)
- N-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-4-yl)-3-(trifluoromethyl)benzenesulfonamide (CAS 338423-29-3)
- 1-(3-(Benzyloxy)pyridin-2-yl)-3-(3-phenoxyphenyl)urea (CAS 1023479-69-7)
- Biotin impurity 01 (CAS 33607-60-2)
- Mirogabalin Impurity N10 (CAS 188398-87-0)
- Ledipasvir Impurity 34 (CAS CATO-C4X-331334)
- N-allyl-5-chlorofuran-2-carboxamide (CAS 1197799-95-3)
- 5-oxo-5,6,7,8-tetrahydronaphthalene-2-sulfonamide (CAS 1273608-70-0)
- Ethyl 1-(2-(methylamino)pyridin-4-yl)-1H-pyrazole-4-carboxylate (CAS 1624260-65-6)
- 1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4,4-difluorocyclohexane-1-carboxylic acid (CAS 1986905-26-3)
- 4-Bromo-3-methyl-5-trimethylsilanyl-isoxazole (CAS 54773-30-7)
- 2-(3-Hydroxymercurio-2-methoxypropylcarbamoyl)phenoxyacetic acid 2-[N-(3-Hydroxymercuri-2-methoxypropyl)carbamoyl]phenoxyacetic acid 486-67-9 Mersalyl Mersalyl acid salyrganic acid (CAS 486-67-9)
- Hexapeptide-11 (CAS 100684-36-4)
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