Avanafil Impurity 21 CAS CATO-C4X-111821
| CAS No. | CATO-C4X-111821 |
| Molecular Formula | C20H24Cl2N4O4 |
| Molecular Weight | 455.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Avanafil Impurity 21 (CAS CATO-C4X-111821, C20H24Cl2N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Avanafil Impurity 21 (C20H24Cl2N4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H24Cl2N4O4 |
| Molecular Weight | 455.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Avanafil Standards
- Avanafil Impurity 63 (CAS CATO-C4X-111863)
- Avanafil Impurity 139 (CAS CATO-C4X-1118139)
- Avanafil Impurity 130 (CAS CATO-C4X-1118130)
- Avanafil Impurity 148 (CAS CATO-C4X-1118148)
- Avanafil Impurity 6 (CAS 330784-50-4)
- Avanafil Impurity 104 (CAS CATO-C4X-1118104)
- Avanafil Impurity 46 (CAS 1624833-89-1)
- Avanafil Impurity 99 (CAS 1643811-21-5)
Recommended Standards
- 7,9-Dichloro-2,5-bis(4-methoxyphenyl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazine (CAS 303059-68-9)
- (1E,4E)-1-(2-(6-(2,4-dichlorobenzyl)pyridazin-3-yl)hydrazinyl)-5-(4-methoxyphenyl)penta-1,4-dien-3-one (CAS 860649-37-2)
- 8-Bromo-2-(methylthio)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one (CAS 1300611-33-9)
- 2-(2-(2-(2-Bromo-4-(tert-butyl)phenoxy)acetyl)hydrazine-1-carbonyl)cyclohexane-1-carboxylic acid (CAS 671795-42-9)
- Memantine Impurity 5 (CAS 19982-07-1)
- Lenalidomide Impurity 30 (CAS 13726-85-7)
- Warfarin Impurity 16 (CAS CATO-C4X-142916)
- N-(4-(heptyloxy)phenyl)acetamide (CAS 55792-60-4)
- 6-(Pyrimidin-2-yl)hexan-1-ol (CAS 121356-80-7)
- 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol mononitrate (CAS 67085-12-5)
- Ethyl 2-(4-chloroquinolin-2-yl)acetate (CAS 1092287-64-3)
- Ubrogepant Impurity 29 (CAS CATO-C4X-340229)
- tert-Butyl 2-methyl-3-{[(pyridin-4-yl)methyl]amino}propanoate (CAS 1221341-40-7)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
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