Canagliflozin Impurity 101 CAS CATO-C4X-1123101
| CAS No. | CATO-C4X-1123101 |
| Molecular Formula | C18H14FIS2 |
| Molecular Weight | 440.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Canagliflozin Impurity 101 (CAS CATO-C4X-1123101, C18H14FIS2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Canagliflozin Impurity 101 (C18H14FIS2) is characterized by sulfur-containing functionality, fluorine/iodine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Canagliflozin Impurity 101 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14FIS2 |
| Molecular Weight | 440.34 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Sulfur Atoms | 2 |
Related Canagliflozin Standards
- Canagliflozin Impurity 100 (CAS CATO-C4X-1123100)
- Canagliflozin Impurity 90 (CAS CATO-C4X-112390)
- Canagliflozin Impurity 88 (CAS CATO-C4X-112388)
- Canagliflozin (CAS 842133-18-0)
- Canagliflozin Impurity 1 (CAS 1589590-87-3)
- Canagliflozin Impurity 103 (CAS CATO-C4X-1123103)
- Canagliflozin Impurity 2 (CAS 2161394-94-9)
- Canagliflozin Impurity 26 (CAS CATO-C4X-112326)
Recommended Standards
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