Palbociclib Impurity 167 CAS CATO-C4X-1125167
| CAS No. | CATO-C4X-1125167 |
| Molecular Formula | C22H30BrN5O3 |
| Molecular Weight | 492.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Palbociclib Impurity 167.
As a process- or degradation-related impurity, Palbociclib Impurity 167 (CAS CATO-C4X-1125167, C22H30BrN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Palbociclib Impurity 167 (C22H30BrN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Palbociclib Impurity 167 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H30BrN5O3 |
| Molecular Weight | 492.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Palbociclib Standards
- Palbociclib Impurity 101 (CAS CATO-C4X-1125101)
- Palbociclib Impurity 145 (CAS CATO-C4X-1125145)
- Palbociclib Impurity 80 (CAS CATO-C4X-112580)
- Palbociclib Impurity 109 (CAS 1974279-20-3)
- Palbociclib Impurity 187 (CAS CATO-C4X-1125187)
- Palbociclib Impurity 136 (CAS CATO-C4X-1125136)
- Palbociclib Impurity 103 (CAS 2270982-31-3)
- Palbociclib Impurity 79 (CAS CATO-C4X-112579)
Recommended Standards
- Butyl 6-bromo-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoline-2-carboxylate (CAS 887589-51-7)
- 3-((3,4-Dichlorobenzyl)thio)-5-((naphthalen-1-yloxy)methyl)-4-phenyl-4H-1,2,4-triazole (CAS 383145-90-2)
- 3-Methyl-4-[3-(trifluoromethyl)benzoyl]-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317833-58-2)
- 4-Methylumbelliferyl 2-3-4-tri-O-acetyl-α-L-idopyranosiduronic acid methyl ester (CAS 128095-50-1)
- Indocyanine Green Impurity 46 (CAS CATO-C4X-250346)
- Berberine Impurity 29 (CAS 2375597-30-9)
- Vonoprazan Fumarate Impurity 85(See C4X-102077) (CAS CATO-C4X-102085)
- (S)-1-(3-chloro-4-fluorophenyl)-2,2-dimethylpropan-1-amine (CAS 1390726-25-6)
- Methyl 4-hydroxy-2,5-dihydrofuran-3-carboxylate (CAS 1040396-68-6)
- Diethyl (4-hydroxy-2,6-dimethylphenyl) phosphate (CAS 1420992-06-8)
- 1-Benzyl-3,5-dimethylpiperidin-4-ol (CAS 91599-86-9)
- (4-Bromo-2-(trifluoromethyl)phenyl)boronic acid (CAS 1394346-22-5)
- 5-Amino-3-(2-furyl)-1H-1,2,4-triazole (CAS 3663-61-4)
- Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 75976-10-2)
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