Sildenafil Impurity 259 CAS CATO-C4X-1128259
| CAS No. | CATO-C4X-1128259 |
| Molecular Formula | C15H15ClN4O2 |
| Molecular Weight | 318.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sildenafil Impurity 259 (CAS CATO-C4X-1128259, C15H15ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sildenafil Impurity 259 (C15H15ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 318.76 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sildenafil Impurity 259 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H15ClN4O2 |
| Molecular Weight | 318.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Sildenafil Standards
- Sildenafil Impurity 101 (CAS CATO-C4X-1128101)
- Sildenafil Impurity 299 (CAS CATO-C4X-1128299)
- Sildenafil Impurity 69 (CAS CATO-C4X-112869)
- Sildenafil Impurity 77 (CAS CATO-C4X-112877)
- Sildenafil Impurity 2 (CAS 332374-42-2)
- Sildenafil Impurity 31 (CAS CATO-C4X-112831)
- Sildenafil Impurity 263 (CAS CATO-C4X-1128263)
- Sildenafil Impurity 298 (CAS CATO-C4X-1128298)
Recommended Standards
- n-(6-Amino-2,4-dioxo-1-propyl-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-n-(2-methoxyethyl)acetamide (CAS 743444-52-2)
- 3-{[(2-chlorophenyl)sulfanyl]methyl}-1-benzofuran-2-carboxylic acid (CAS 1039967-31-1)
- Ethyl 7-(4-chlorophenyl)-5-methyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate (CAS 329796-03-4)
- N-(3-Chloro-4-fluorophenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142200-17-6)
- Tizanidine Impurity 46 (CAS CATO-C4X-144546)
- Palonosetron Impurity 41 (CAS CATO-C4X-110541)
- Gefitinib Impurity 18 (CAS 50413-44-0)
- 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (CAS 1426337-41-8)
- 1-(5-Chloro-2-methoxyphenyl)guanidine (CAS 75087-92-2)
- 3-(Benzyloxy)-5-fluoro-4-methylbenzoic acid (CAS 1215030-99-1)
- 2-(2,2-Dimethylpropyl)-1,3-thiazole-5-carboxylic acid (CAS 1344093-98-6)
- 6-(1-Ethyl-3-iodo-1H-pyrazol-4-yl)pyrimidin-2(1H)-one (CAS 1269440-92-7)
- 3-Chloro-1-(4-chlorophenyl)propan-1-ol (CAS 25574-18-9)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com