Gefitinib Impurity 18 CAS 50413-44-0
| CAS No. | 50413-44-0 |
| Molecular Formula | C9H11NO4 |
| Molecular Weight | 197.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Gefitinib Impurity 18 (CAS 50413-44-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11NO4 and a molecular weight of 197.19 g/mol.
Gefitinib Impurity 18 (C9H11NO4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11NO4 |
| Molecular Weight | 197.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 1 |
Related Gefitinib Standards
- Gefitinib Impurity N18 (CAS 58749-47-6)
- Gefitinib Impurity 28 (CAS 1379208-77-1)
- Gefitinib Impurity 4 (CAS 179688-52-9)
- Gefitinib Impurity 8 (CAS 379228-50-9)
- Gefitinib Impurity 85 (CAS CATO-C4X-111785)
- Gefitinib Impurity 34 (CAS 194423-17-1)
- Gefitinib Impurity 92 (CAS CATO-C4X-111792)
- Gefitinib Impurity 45 (CAS 350-30-1)
Recommended Standards
- Citalopram Impurity 9 (CAS CATO-C4X-11099)
- Sildenafil Impurity 99 (CAS CATO-C4X-112899)
- 2-Amino-4,5-dimethoxybenzoic Acid (CAS 5653-40-7)
- 5-Acetamido-1H-pyrazole-4-carboxylic acid ethyl ester (CAS CATO-C4X-145810)
- Finerenone Impurity 287 (CAS CATO-C4X-2880287)
- Mitoxantrone Impurity 21 (CAS CATO-C4X-103421)
- Paliperidone Impurity 52 (CAS 2640158-02-5)
- 5-(Tert-butoxycarbonyl)-8-oxa-5-azaspiro[3.5]Nonane-2-carboxylic acid (CAS 1251022-92-0)
- 2-(5-Chloro-1H-indol-3-yl)acetonitrile (CAS 81630-83-3)
- (6-(2-Methylmorpholino)pyridin-3-yl)methanamine (CAS 926258-47-1)
- HO-PEG21-OH (CAS 928211-42-1)
- 89454-67-1 Benzonitrile, 4-(1H-imidazo[4,5-b]pyridin-2-yl)- DTXSID40356972 (CAS 89454-67-1)
- 4-(3-Ethylheptan-2-yl)phenol (CAS 186825-39-8)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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