Neratinib Impurity 1 CAS CATO-C4X-11341
| CAS No. | CATO-C4X-11341 |
| Molecular Formula | C50H38Cl2N10O6 |
| Molecular Weight | 945.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Neratinib Impurity 1.
CATO supplies Neratinib Impurity 1 (CAS CATO-C4X-11341), a pharmacopoeial impurity reference standard (molecular formula C50H38Cl2N10O6, MW 945.81 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Neratinib Impurity 1 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 945.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C50H38Cl2N10O6 |
| Molecular Weight | 945.81 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 36.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 10 |
Related Neratinib Standards
- Neratinib Impurity 34 (CAS CATO-C4X-113434)
- Neratinib Impurity 53 (CAS CATO-C4X-113453)
- Neratinib Impurity 11 (CAS 1144516-16-4)
- Neratinib Impurity 18 (CAS 1144516-17-5)
- Neratinib Impurity 6 (CAS CATO-C4X-11346)
- Neratinib Impurity 45 (CAS CATO-C4X-113445)
- Neratinib Impurity 19 (CAS 1376619-98-5)
- Neratinib Impurity 35 (CAS CATO-C4X-113435)
Recommended Standards
- AZD 4320 (CAS 1357576-48-7)
- N-(9-Fluorenylmethoxycarbonyl)-O-(2,3,6,2',3',4',6'-hepta-O-acetyl-b-D-lactosyl)-L-serine (CAS 169275-84-7)
- Ubidecarenone (Coenzyme Q10) Impurity 15 (CAS CATO-C4X-137615)
- PC DBCO-PEG4-NHS ester (CAS 2055025-02-8)
- Linagliptin Impurity 110 (CAS CATO-C4X-1101110)
- Fulvestrant Impurity 21 (CAS 261506-24-5)
- Losartan Impurity 61 (CAS CATO-C4X-168361)
- (3E)-5-bromo-3-[(2,4-difluorophenyl)imino]-2,3-dihydro-1H-indol-2-one 118416-28-7 MS-8800 (CAS 118416-28-7)
- ((1-Ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane (CAS 31469-16-6)
- Bromotridecylmagnesium (CAS 117711-00-9)
- Cisapride Impurity 1 (Nor Cisapride) (CAS 83863-69-8)
- Ethyl 2,2-difluoro-2-(5-methylpyridin-2-yl)acetate (CAS 503627-67-6)
- 1-(4-Fluorobenzyl)-3-((1-(thiophen-2-ylmethyl)piperidin-4-yl)methyl)urea (CAS 1207019-61-1)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com